前列腺素E在人肝细胞癌恶性转化和进展中的合成与信号传导

PGE synthesis and signaling in malignant transformation and progression of human hepatocellular carcinoma.

作者信息

Zang Shengbing, Ma Xiaojie, Wu Yanbin, Liu Wenwen, Cheng Haili, Li Jiasi, Liu Jingfeng, Huang Aimin

机构信息

Department of Pathology and Institute of Oncology, School of Basic Medical Science, Fujian Medical University, Fuzhou, 350004, China.

Department of Pathology and Institute of Oncology, School of Basic Medical Science, Fujian Medical University, Fuzhou, 350004, China; Department of Pathology, Henan Provincial Chest Hospital, Zhengzhou, 450000, China.

出版信息

Hum Pathol. 2017 May;63:120-127. doi: 10.1016/j.humpath.2017.02.018. Epub 2017 Mar 12.

DOI:10.1016/j.humpath.2017.02.018

PMID:28300577

Abstract

Prostaglandin E 2 (PGE), which is the most abundant prostaglandin produced in hepatocellular carcinoma (HCC), may be involved in hepatocarcinogenesis. Here, the amount of PGE was significantly increased in HCC tissue and adjacent noncancerous tissues relative to normal liver tissue (P<.001). In addition, the expression of EP2 receptor was considerably upregulated in HCC tissue compared with the expression of EP1 (P<.05), EP3 (P<.01), and EP4 (P<.01) receptor. The expression of EP2 receptor was positively correlated with the level of PGE in HCC tissue (P<.001). Furthermore, PGE significantly increased proliferation and invasion potential of human HCC cells. However, antagonism of EP2 signaling suppressed PGE-induced growth and invasion in human HCC cells. Taken together, upregulation of PGE level was associated with proliferation and invasion potential of HCC, and EP2 receptor predominately mediated the function of PGE in the transformation and progression of HCC.

摘要

前列腺素E2（PGE）是肝细胞癌（HCC）中产生最多的前列腺素，可能参与肝癌发生过程。在此，相对于正常肝组织，HCC组织和癌旁非癌组织中PGE的含量显著增加（P<0.001）。此外，与EP1（P<0.05）、EP3（P<0.01）和EP4（P<0.01）受体的表达相比，HCC组织中EP2受体的表达明显上调。EP2受体的表达与HCC组织中PGE的水平呈正相关（P<0.001）。此外，PGE显著增加人HCC细胞的增殖和侵袭潜能。然而，EP2信号的拮抗作用抑制了PGE诱导的人HCC细胞生长和侵袭。综上所述，PGE水平上调与HCC的增殖和侵袭潜能相关，并且EP2受体在很大程度上介导了PGE在HCC转化和进展中的功能。