在一项关于封闭性和保湿性的双盲研究中，0.05%丙酸氯倍他索洗剂相比0.05%丙酸氯倍他索乳膏具有更好的保湿效果。

Halobetasol Propionate Lotion, 0.05% Provides Superior Hydration Compared to Halobetasol Propionate Cream, 0.05% in a Double-Blinded Study of Occlusivity and Hydration.

作者信息

Grove Gary, Zerweck Charles, Houser Tim, Andrasfay Anthony, Gauthier Bob, Holland Charles, Piacquadio Daniel

出版信息

J Drugs Dermatol. 2017 Feb 1;16(2):140-144.

Abstract

BACKGROUND

This study measured skin hydration and occlusivity of two test products [halobetasol propionate lotion, 0.05% (HBP Lotion) and Ultravate® (halobetasol propionate) cream, 0.05% (HBP Cream)] at 2, 4, and 6 hours after application to skin test sites previously challenged by dry shaving, which was performed to compromise the integrity of the stratum corneum barrier.

METHODS

Trans-epidermal water loss (TEWL), an indicator of skin barrier function, was measured using cyberDERM, inc. RG-1 evaporimeter. Skin hydration was evaluated using IBS SkiCon-200 conductance meter. Test products were applied bilaterally on dry-shaved sites on the volar forearm sites, according to a randomization scheme, with two test sites untreated to serve as "dry-shaved" controls. TEWL and conductance were measured at 2, 4, and 6 hours post-treatment.

RESULTS

HBP Lotion displayed a significant increase in skin hydration at 2, 4, and 6 hours post-treatment compared to the baseline values and dry-shaved controls (each, P less than 0.001). However, HBP Cream produced statistically significant increased skin hydration only after 6 hours (P less than 0.05). HBP Lotion was significantly more effective than HBP Cream in increasing skin hydration at 2 and 4 hours post-treatment (each, P less than 0.001), and had a directional advantage (not statistically significant) at 6 hours. Neither test product had a significant occlusive effect as measured by TEWL at 2, 4, and 6 hours post-application.

CONCLUSION

Both formulations of HBP (Lotion and Cream) contributed to skin moisturization, as measured by skin conductance. HBP Lotion produced a significantly more rapid onset and higher level of moisturization at 2 and 4 hours post-application compared to HBP Cream. The TEWL results indicate that neither HBP Lotion nor HBP Cream provided any significant occlusivity to the skin.

J Drugs Dermatol. 2017;16(2):140-144.

摘要

背景

本研究测量了两种受试产品[0.05%丙酸氯倍他索洗剂（HBP洗剂）和0.05%卤米松乳膏（HBP乳膏）]在涂抹于先前因干剃而受损的皮肤测试部位后2小时、4小时和6小时的皮肤水合作用和封闭性，干剃是为了破坏角质层屏障的完整性。

方法

使用cyberDERM公司的RG-1蒸发仪测量经表皮水分流失（TEWL），这是皮肤屏障功能的一个指标。使用IBS SkiCon-200电导仪评估皮肤水合作用。根据随机方案，将受试产品双侧涂抹于掌侧前臂干剃部位，有两个测试部位不进行处理作为“干剃”对照。在治疗后2小时、4小时和6小时测量TEWL和电导。

结果

与基线值和干剃对照相比，HBP洗剂在治疗后2小时、4小时和6小时皮肤水合作用显著增加（均P<0.001）。然而，HBP乳膏仅在6小时后皮肤水合作用有统计学显著增加（P<0.05）。在治疗后2小时和4小时，HBP洗剂在增加皮肤水合作用方面显著比HBP乳膏更有效（均P<0.001），并且在6小时时有方向性优势（无统计学显著性）。在涂抹后2小时、4小时和6小时，通过TEWL测量，两种受试产品均无显著的封闭作用。