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转录中的FUBP/KH结构域蛋白：回到未来。

FUBP/KH domain proteins in transcription: Back to the future.

作者信息

Quinn Leonie M

机构信息

a Department of Cancer Biology and Therapeutics , The John Curtin School of Medical Research, The Australian National University , Canberra , ACT , Australia.

出版信息

Transcription. 2017 May 27;8(3):185-192. doi: 10.1080/21541264.2017.1293595. Epub 2017 Feb 16.

DOI:10.1080/21541264.2017.1293595
PMID:28301294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5501386/
Abstract

Drosophila genetic studies demonstrate that cell and tissue growth regulation is a primary developmental function of P-element somatic inhibitor (Psi), the sole ortholog of FUBP family RNA/DNA-binding proteins. Psi achieves growth control through interaction with Mediator, observations that should put to rest controversy surrounding Pol II transcriptional functions for these KH domain proteins.

摘要

果蝇遗传学研究表明，细胞和组织生长调控是P因子体细胞抑制剂（Psi）的主要发育功能，Psi是FUBP家族RNA/DNA结合蛋白的唯一直系同源物。Psi通过与中介体相互作用实现生长控制，这些观察结果应该平息围绕这些KH结构域蛋白的聚合酶II转录功能的争议。

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本文引用的文献

1
Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth.确定FBP/KSRP蛋白的基本功能：果蝇Psi与中介体复合物相互作用以调节MYC转录和组织生长。
Nucleic Acids Res. 2016 Sep 19;44(16):7646-58. doi: 10.1093/nar/gkw461. Epub 2016 May 20.
2
The PSI-U1 snRNP interaction regulates male mating behavior in Drosophila.PSI-U1 小核核糖核蛋白相互作用调节果蝇的雄性交配行为。
Proc Natl Acad Sci U S A. 2016 May 10;113(19):5269-74. doi: 10.1073/pnas.1600936113. Epub 2016 Apr 25.
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RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription.RNA聚合酶II调节拓扑异构酶1的活性以促进高效转录。
Cell. 2016 Apr 7;165(2):357-71. doi: 10.1016/j.cell.2016.02.036.
4
Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels.远上游元件结合蛋白在胚胎发育、造血及稳定Myc表达水平中起关键作用。
Am J Pathol. 2016 Mar;186(3):701-15. doi: 10.1016/j.ajpath.2015.10.028. Epub 2016 Jan 14.
5
Single-Stranded DNA-Binding Transcriptional Regulator FUBP1 Is Essential for Fetal and Adult Hematopoietic Stem Cell Self-Renewal.单链DNA结合转录调节因子FUBP1对胎儿和成人造血干细胞自我更新至关重要。
Cell Rep. 2015 Jun 30;11(12):1847-55. doi: 10.1016/j.celrep.2015.05.038. Epub 2015 Jun 18.
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Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.在果蝇XPB模型中，依赖Hfp的dMYC转录抑制缺陷是组织过度生长的根本原因。
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