转录中的FUBP/KH结构域蛋白：回到未来。
FUBP/KH domain proteins in transcription: Back to the future.
作者信息
Quinn Leonie M
机构信息
a Department of Cancer Biology and Therapeutics , The John Curtin School of Medical Research, The Australian National University , Canberra , ACT , Australia.
出版信息
Transcription. 2017 May 27;8(3):185-192. doi: 10.1080/21541264.2017.1293595. Epub 2017 Feb 16.
Abstract
Drosophila genetic studies demonstrate that cell and tissue growth regulation is a primary developmental function of P-element somatic inhibitor (Psi), the sole ortholog of FUBP family RNA/DNA-binding proteins. Psi achieves growth control through interaction with Mediator, observations that should put to rest controversy surrounding Pol II transcriptional functions for these KH domain proteins.
摘要
果蝇遗传学研究表明，细胞和组织生长调控是P因子体细胞抑制剂（Psi）的主要发育功能，Psi是FUBP家族RNA/DNA结合蛋白的唯一直系同源物。Psi通过与中介体相互作用实现生长控制，这些观察结果应该平息围绕这些KH结构域蛋白的聚合酶II转录功能的争议。
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