与核小体占据的增强子处H2A.Z和p300/CBP组合相关的两种可能的先锋模式。
Two possible modes of pioneering associated with combinations of H2A.Z and p300/CBP at nucleosome-occupied enhancers.
作者信息
Cauchy Pierre, Koch Frederic, Andrau Jean-Christophe
机构信息
a Max Planck Institute of Immunobiology and Epigenetics , Department of Cellular and Molecular Immunology , Freiburg im Breisgau , Germany.
b Max Planck Institute for Molecular Genetics , Department of Developmental Genetics , Berlin , Germany.
出版信息
Transcription. 2017 May 27;8(3):179-184. doi: 10.1080/21541264.2017.1291395. Epub 2017 Feb 13.
Abstract
Pioneer transcription factors are defined by their ability to bind nucleosome-occupied regions. Here, we discuss the properties of nucleosomes bound by pioneers at enhancer regions. We describe how select pioneers bind nucleosome-occupied or -depleted enhancer sites. Importantly, by revisiting and expanding existing data sets, we show differential H2A.Z and p300/CBP association at bound enhancers, highlighting two possible pioneering modes.
摘要
先驱转录因子是根据其结合核小体占据区域的能力来定义的。在此，我们讨论先驱因子在增强子区域所结合的核小体的特性。我们描述了特定先驱因子如何结合核小体占据或未占据的增强子位点。重要的是，通过重新审视和扩展现有数据集，我们展示了在结合的增强子处H2A.Z和p300/CBP的差异关联，突出了两种可能的先驱模式。
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