Pierre M, Gavaret J M, Matricon C, Pomerance M, Jacquemin C, Toru-Delbauffe D
Unité de Recherche sur la Glande Thyroïde et la Régulation Hormonale, INSERM Unité 96, Le Kremlin-Bicêtre, France.
FEBS Lett. 1988 Feb 15;228(2):219-22. doi: 10.1016/0014-5793(88)80002-4.
Forskolin and isoproterenol, agonists of adenylate cyclase activity, and dibutyryl cyclic AMP, stimulated an S6 kinase activity in astroglial cells. This activity was insensitive to the thermostable inhibitor of cyclic AMP-dependent protein kinase and had the same behaviour on a DEAE-Sephacel column as the mitogen stimulated S6 kinase. These observations support the idea that the cyclic AMP cascade, as well as various growth factors, can activate S6 kinase.
毛喉素和异丙肾上腺素，腺苷酸环化酶活性的激动剂，以及二丁酰环磷酸腺苷，均可刺激星形胶质细胞中的S6激酶活性。这种活性对环磷酸腺苷依赖性蛋白激酶的热稳定抑制剂不敏感，并且在二乙氨基乙基纤维素柱上的行为与有丝分裂原刺激的S6激酶相同。这些观察结果支持这样一种观点，即环磷酸腺苷级联反应以及各种生长因子均可激活S6激酶。
