Wright Mayes Emily, Cole Emily D, Dang Sabin, Novais Eduardo A, Vuong Laurel, Mendoza-Santiesteban Carlos, Duker Jay S, Hedges Thomas R
New England Eye Center (EWM, EDC, SD, EAN, LV, CM-S, JSD, TRH), Tufts Medical Center, Boston, Massachusetts; and Universidade Federal de São Paulo (EAN), Escola Paulista de Medicina, São Paulo, Brazil.
J Neuroophthalmol. 2017 Dec;37(4):358-364. doi: 10.1097/WNO.0000000000000493.
Optical coherence tomography angiography (OCTA) has demonstrated good utility in qualitative analysis of retinal and choroidal vasculature and therefore may be relevant in the diagnostic and treatment efforts surrounding nonarteritic anterior ischemic optic neuropathy (NAION).
Retrospective, cross-sectional study of 10 eyes of 9 patients with a previous or new diagnosis of NAION that received imaging with OCTA between November 2015 and February 2016. Two independent readers qualitatively analyzed the retinal peripapillary capillaries (RPC) and peripapillary choriocapillaris (PCC) for flow impairment. Findings were compared with automated visual field and structural optical coherence tomography (OCT) studies.
Flow impairment seen on OCTA in the RPC corresponded to structural OCT deficits of the retinal nerve fiber layer (RNFL) and ganglion cell layer complex (GCC) in 80% and 100% of eyes, respectively, and to automated visual field deficits in 90% of eyes. Flow impairment seen on OCTA in the PCC corresponded to structural OCT deficits of the RNFL and GCC in 70% and 80% of eyes, respectively, and to visual field deficits in 60%-80% of eyes.
OCTA can noninvasively visualize microvascular flow impairment in patients with NAION.
光学相干断层扫描血管造影（OCTA）已在视网膜和脉络膜血管系统的定性分析中显示出良好的效用，因此可能与非动脉性前部缺血性视神经病变（NAION）的诊断和治疗相关。
对2015年11月至2016年2月间接受OCTA成像的9例既往或新诊断为NAION的患者的10只眼进行回顾性横断面研究。两名独立的阅片者对视网膜乳头周围毛细血管（RPC）和乳头周围脉络膜毛细血管（PCC）的血流受损情况进行定性分析。将结果与自动视野检查和结构光学相干断层扫描（OCT）研究进行比较。
OCTA显示RPC血流受损分别与80%的眼视网膜神经纤维层（RNFL）和100%的眼神经节细胞层复合体（GCC）的结构OCT缺损相对应，与90%的眼自动视野缺损相对应。OCTA显示PCC血流受损分别与70%的眼RNFL和80%的眼GCC的结构OCT缺损相对应，与60%-80%的眼视野缺损相对应。
OCTA可以无创地显示NAION患者的微血管血流受损情况。
