Nefzi Dhouha, Chaabani Lotfi, Jouini Arij, Abroug Nesrine, Ksiaa Imen, Khairallah Moncef
Ophthalmology Department, Kasserine Regional Hospital. Faculty of Medicine of Sousse, University of Sousse, Tunisia.
Ophthalmology Department, Fattouma Bourguiba University Hospital, Monastir. Faculty of Medicine of Monastir, University of Monastir, Tunisia.
Tunis Med. 2024 Oct 5;102(10):653-658. doi: 10.62438/tunismed.v102i10.4986.
to describe and analyze peripapillary microvascular changes in eyes with optic neuropathies using optical coherence tomography angiography (OCTA).
In this cross-sectional observational study, 63 eyes of 48 patients with different causes of optic neuropathy and 36 healthy control eyes were evaluated by optical coherence tomography (OCT) and OCTA (Topcon DRI OCT; Triton) between January 2018 and December 2018 at the Fattouma Bourguiba ophthalmology department in Monastir.
Vascular changes were more frequent in acute non arteritic anterior ischemic optic neuropathy (NAION) than in optic neuritis. Eyes with optic atrophy had capillary rarefaction corresponding to the area of thinning of the peripapillary optic fiber layer (RNFL). The peripapillary vascular density (PVD) was lower (p=0.036) in case of optic atrophy compared to normal eyes. For non arteritic ischemic optic neuropathy and for chronic retrobulbar optic neuritis (NORB), a positive correlation between visual acuity and PVD was observed (p<0.05). An inversely proportional correlation between the PVD and the duration of evolution was noted. In the multivariate study, high blood pressure was a systemic factor correlated with peripapillary microvascular damages.
OCTA showed a reduction in PVD and greater vascular changes in acute non-arteritic ischemic optic neuropathy than in edematous optic neuritis. At the atrophic stage, the PVD was reduced. Hypertension was an independent factor correlated with peripapillary microvascular damages.
使用光学相干断层扫描血管造影（OCTA）描述和分析视神经病变患者视乳头周围微血管变化。
在这项横断面观察性研究中，2018年1月至2018年12月期间，在莫纳斯提尔的法图玛·布尔吉巴眼科，对48例不同病因视神经病变患者的63只眼和36只健康对照眼进行了光学相干断层扫描（OCT）和OCTA（Topcon DRI OCT；Triton）评估。
急性非动脉炎性前部缺血性视神经病变（NAION）中的血管变化比视神经炎中更常见。视神经萎缩的眼睛在视乳头周围视神经纤维层（RNFL）变薄区域有毛细血管稀疏。与正常眼睛相比，视神经萎缩时视乳头周围血管密度（PVD）较低（p = 0.036）。对于非动脉炎性缺血性视神经病变和慢性球后视神经炎（NORB），观察到视力与PVD之间呈正相关（p < 0.05）。注意到PVD与病程呈反比关系。在多变量研究中，高血压是与视乳头周围微血管损伤相关的全身因素。
OCTA显示，急性非动脉炎性缺血性视神经病变中PVD降低且血管变化比水肿性视神经炎中更明显。在萎缩阶段，PVD降低。高血压是与视乳头周围微血管损伤相关的独立因素。
