Neuro-ophthalmology and Strabismus Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Retina Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Indian J Ophthalmol. 2023 May;71(5):2020-2026. doi: 10.4103/IJO.IJO_2537_22.
To study the long-term microvasculature changes at the macula and the optic disk in eyes with nonarteritic anterior ischemic optic neuropathy (NAION).
Patients with acute NAION of less than 6 weeks duration were included. Optical coherence tomography angiography (OCTA) of the macula and the optic disk was performed at baseline, 3 and 6 months and compared with the controls.
The mean age of 15 patients was 52.25 (±9.06) years. The whole image superficial peripapillary density (42.49 ± 5.28) was significantly low when compared to that of control eyes (46.36 ± 2.09); similarly, radial peripapillary capillary density (49.35 ± 5.64) was also significantly reduced when compared to controls (53.45 ± 1.96, P < 0.05). These parameters showed significant progressive decrease at 3 and 6 months (P < 0.05). At the macula, both superficial (41.83 ± 3.64) and deep macular vasculature densities (47.30 ± 2.04) were significantly reduced when compared to control eyes (52.15 ± 4.84 and 55.13 ± 1.81, respectively). The vascular density at the macula remained stable at 3- and 6-months period.
The study shows that the microvasculature in case of NAION is significantly reduced both in peripapillary area and in macular area.
研究非动脉炎性前部缺血性视神经病变（NAION）患者黄斑和视盘的长期微血管变化。
纳入急性 NAION 病程少于 6 周的患者。在基线、3 个月和 6 个月时对黄斑和视盘进行光学相干断层扫描血管造影（OCTA），并与对照组进行比较。
15 例患者的平均年龄为 52.25（±9.06）岁。与对照组相比，全像浅层视盘周围密度（42.49 ± 5.28）显著降低；同样，放射状视盘周围毛细血管密度（49.35 ± 5.64）也显著降低（分别为 53.45 ± 1.96，P < 0.05）。这些参数在 3 个月和 6 个月时显示出显著的渐进性下降（P < 0.05）。在黄斑区，浅层（41.83 ± 3.64）和深层黄斑血管密度（47.30 ± 2.04）均明显低于对照组（分别为 52.15 ± 4.84 和 55.13 ± 1.81）。黄斑区的血管密度在 3 个月和 6 个月时保持稳定。
研究表明，NAION 患者的视盘周围和黄斑区的微血管明显减少。
