He Fei, Qi Qi, Li Xu, Xiao Rendong, Xu Qiuping, Xiong Weimin, Liu Zhiqiang, Cai Lin
Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350108, China.
Department of Thoracic Surgery, the First Clinical Medical College of Fujian Medical University, Fuzhou 350108, China.
Zhongguo Fei Ai Za Zhi. 2017 Mar 20;20(3):149-156. doi: 10.3779/j.issn.1009-3419.2017.03.02.
Hypoxia inducible factor-1α (HIF-1α) is associated with the progression and metastasis of lung cancer. There are, however, few studies on the relationship between the single nucleotide polymorphisms of HIF-1α and susceptibility to lung cancer. Therefore, we aimed to investigate the relationship between indoor air pollution, HIF-1α rs2057482, and the susceptibility to primary lung cancer of the Fujian Han population.
The present study is a hospital-based case-control study. We recruited 1,096 lung cancer and 1,110 controls that were admitted to the Department of Thoracic Surgery of the First Affiliated Hospital and Union Hospital of Fujian Medical University and Fuzhou General Hospital of Nanjing Military Region from January 2006 to December 2012. The primary lung cancer cases were identified via pathological methods. Both case and control groups received questionnaires. Genotyping of HIF-1α gene rs2057482 locus polymorphism in all subjects were analyzed by MALDI-TOF-MS technique.
Individuals who carried the T-genotype of HIF-1α rs2057482 were more susceptible to small cell carcinoma (odds ratio of 1.725, 95%CI: 1.047-2.842). After adjusting for general and lung cancer-related factors, we found that in the co-dominant genetic model, rs2057482 TT carriers were 2.195 times more likely to develop lung cancer than CC carriers (95%CI: 1.038-4.463) in the population that were exposed to passive smoking. In the dominant genetic model, the risk of lung cancer was 1.911 times (95%CI: 1.121-3.258) that in the carriers of the rs2057482 T allele with a family history of cancer. In the recessive genetic model, rs2057482 TT carriers had a 0.159-fold increased risk of lung cancer (95%CI: 0.028-0.920) than TC+CC carriers in people with a history of lung disease. In the additive genetic model, the risk of lung cancer in rs2057482 TC+TT carriers was 1.542 times (95%CI: 1.107-2.340) that in the CC family of people with a family history of cancer.
CONCLUSIONS: HIF-1α rs2057482 may be associated with lung cancer susceptibility. .
缺氧诱导因子-1α（HIF-1α）与肺癌的进展和转移相关。然而，关于HIF-1α单核苷酸多态性与肺癌易感性之间关系的研究较少。因此，我们旨在探讨室内空气污染、HIF-1α rs2057482与福建汉族人群原发性肺癌易感性之间的关系。
本研究是一项基于医院的病例对照研究。我们招募了2006年1月至2012年12月期间在福建医科大学附属第一医院、协和医院以及南京军区福州总医院胸外科住院的1096例肺癌患者和1110例对照。原发性肺癌病例通过病理方法确诊。病例组和对照组均接受问卷调查。采用基质辅助激光解吸电离飞行时间质谱技术（MALDI-TOF-MS）分析所有受试者HIF-1α基因rs2057482位点的多态性。
携带HIF-1α rs2057482的T基因型个体更易患小细胞癌（优势比为1.725，95%置信区间：1.047 - 2.842）。在调整一般因素和肺癌相关因素后，我们发现，在共显性遗传模型中，在被动吸烟人群中，rs2057482 TT携带者患肺癌的可能性是CC携带者的2.195倍（95%置信区间：1.038 - 4.463）。在显性遗传模型中，有癌症家族史的rs2057482 T等位基因携带者患肺癌的风险是1.911倍（95%置信区间：1.121 - 3.258）。在隐性遗传模型中，有肺部疾病史的人群中，rs2057482 TT携带者患肺癌的风险比TC + CC携带者高0.159倍（95%置信区间：0.028 - 0.920）。在加性遗传模型中，有癌症家族史的人群中，rs2057482 TC + TT携带者患肺癌的风险是CC携带者的1.542倍（95%置信区间：1.107 - 2.340）。
HIF-1α rs2057482可能与肺癌易感性相关。
