Gorensek M J, Stewart R W, Keys T F, McHenry M C, Goormastic M
Department of Infectious Diseases, Cleveland Clinic Foundation, Ohio.
J Infect Dis. 1988 Mar;157(3):515-22. doi: 10.1093/infdis/157.3.515.
Thirty-four consecutive heart transplant recipients were studied over a two-year period for evidence of cytomegalovirus (CMV) infection. Twenty-three episodes of CMV infection were identified; 19 of these occurred within 120 d after transplantation and were statistically analyzed. Fifteen potential risk factors were evaluated, including the following: pretransplant CMV serological status of donor and recipient; recipient's age, sex, race, and cardiac disease; number and type of blood products transfused; type and intensity of immunosuppression; occurrence of rejection; and leukopenia. The Cox proportional hazards model identified both greater than average steroid dosage and positive recipient CMV serology as significant risk factors for CMV infection (P = .014 and .048, respectively). In a separate analysis, however, only greater than average steroid dosage was associated with clinically significant CMV infection (P = .005).
在两年的时间里，对34例连续的心脏移植受者进行了研究，以寻找巨细胞病毒（CMV）感染的证据。共发现23例CMV感染病例；其中19例发生在移植后120天内，并进行了统计学分析。评估了15个潜在风险因素，包括：供体和受体移植前的CMV血清学状态；受体的年龄、性别、种族和心脏病情况；输注血液制品的数量和类型；免疫抑制的类型和强度；排斥反应的发生情况；以及白细胞减少症。Cox比例风险模型确定，高于平均剂量的类固醇和受体CMV血清学阳性均为CMV感染的显著风险因素（P值分别为0.014和0.048）。然而，在另一项分析中，只有高于平均剂量的类固醇与临床上显著的CMV感染相关（P = 0.005）。
