Mathias J R, Baskin G S, Reeves-Darby V G, Clench M H, Smith L L, Calhoon J H
Department of Internal Medicine, University of Texas Medical Branch, Galveston 77550-2780.
Dig Dis Sci. 1992 Nov;37(11):1761-8. doi: 10.1007/BF01299872.
After orthotopic heart-lung transplantation and immunosuppression, a patient developed intractable nausea and vomiting in association with chronic cytomegalovirus infection. Chronic intestinal pseudoobstruction was documented by antroduodenal manometric study. The patient was treated with leuprolide acetate with resolution of symptoms and improvement of intestinal motility abnormality. This case demonstrates an association of chronic viral infection with acquired intestinal motor disorders. Gastrointestinal complications that are common after organ transplantation might be due to acquired neuromuscular disease. The potential efficacy of leuprolide in such neuromuscular disorders provides a rationale for diagnostic motility studies in patients with "functional" gastrointestinal disorders.
在进行原位心肺移植和免疫抑制治疗后，一名患者出现了顽固性恶心和呕吐，并伴有慢性巨细胞病毒感染。通过十二指肠测压研究证实存在慢性肠道假性梗阻。该患者接受了醋酸亮丙瑞林治疗，症状得到缓解，肠道动力异常也有所改善。本病例表明慢性病毒感染与获得性肠道运动障碍之间存在关联。器官移植后常见的胃肠道并发症可能归因于获得性神经肌肉疾病。亮丙瑞林在这类神经肌肉疾病中的潜在疗效为对“功能性”胃肠道疾病患者进行诊断性动力研究提供了理论依据。
