Section of Hygiene, Institute of Public Health, Rome, 00168, Italy.
Tisch Cancer Institute, New York, NY, 10029, USA.
Endocrine. 2017 Nov;58(2):368-379. doi: 10.1007/s12020-017-1273-x. Epub 2017 Mar 16.
The incidence of neuroendocrine neoplasms is increasing. This work aimed at: (i) establishing worldwide incidence trend of low-grade neuroendocrine neoplasms; (ii) defining the incidence and temporal trend of high-grade neuroendocrine neoplasms in USA utilizing the Surveillance Epidemiology and End Results database; (iii) comparing trends for low-grade vs. high-grade neuroendocrine neoplasms.
We conducted a literature search on MEDLINE and Scopus databases and incidence trends were plotted for 1973-2012. The Surveillance Epidemiology and End Results database was used to identify incidence rates in USA for 1973-2012. Incidence rates were stratified according to histological grade, gender and ethnicity. Trends were summarized as annual percent change and corresponding 95% confidence interval.
11 studies were identified involving 72,048 cases; neuroendocrine neoplasm incidence rates increased over time in all countries for all sites, except for appendix. In Surveillance Epidemiology and End Results low-grade neuroendocrine neoplasm incidence rate increased from 1.09 in 1973 to 3.51 per 100,000 in 2012. During this interval, high-grade neuroendocrine neoplasm incidence rate increased from 2.54 to 10.52 per 100,000. African Americans had the highest rates of digestive neuroendocrine neoplasms with male prevalence in high-grade.
Our data indicate an increase in the incidence of neuroendocrine neoplasms as a worldwide phenomenon, affecting most anatomical sites and involving both low-grade and high-grade neoplasms.
神经内分泌肿瘤的发病率正在上升。本研究旨在：（i）确定低级别神经内分泌肿瘤的全球发病率趋势；（ii）利用监测、流行病学和最终结果数据库定义美国高级别神经内分泌肿瘤的发病率和时间趋势；（iii）比较低级别与高级别神经内分泌肿瘤的趋势。
我们在 MEDLINE 和 Scopus 数据库中进行了文献检索，并绘制了 1973 年至 2012 年的发病率趋势。利用监测、流行病学和最终结果数据库确定了 1973 年至 2012 年美国的发病率。根据组织学分级、性别和种族对发病率进行分层。趋势以年百分比变化和相应的 95%置信区间进行总结。
共确定了 11 项研究，涉及 72048 例病例；除阑尾外，所有国家的所有部位神经内分泌肿瘤的发病率随着时间的推移都在增加。在监测、流行病学和最终结果中，低级别神经内分泌肿瘤的发病率从 1973 年的 1.09 增加到 2012 年的 3.51/10 万。在此期间，高级别神经内分泌肿瘤的发病率从 2.54 增加到 10.52/10 万。非裔美国人的消化系统神经内分泌肿瘤发病率最高，且高级别肿瘤中男性患病率较高。
我们的数据表明，神经内分泌肿瘤的发病率呈全球性上升趋势，影响大多数解剖部位，涉及低级别和高级别肿瘤。
