Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Medical Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Invest New Drugs. 2017 Aug;35(4):509-517. doi: 10.1007/s10637-017-0449-9. Epub 2017 Mar 16.
The potential of natural substances with immunotherapeutic properties has long been studied. β-glucans, a cell wall component of certain bacteria and fungi, potentiate the immune system against microbes and toxic substances. Moreover, β-glucans are known to exhibit direct anticancer effects and can suppress cancer proliferation through immunomodulatory pathways. Mortality of lung cancer has been alarmingly increasingly worldwide; therefore, treatment of lung cancer is an urgent necessity. Numerous researchers are now dedicated to using β-glucans as a therapy for lung cancer. In the present attempt, we have reviewed the studies addressing therapeutic effects of β-glucans in primary and metastatic lung cancer published in the time period of 1991-2016.
具有免疫治疗特性的天然物质的潜力早已被研究。β-葡聚糖是某些细菌和真菌细胞壁的组成部分，可增强免疫系统对抗微生物和有毒物质的能力。此外，β-葡聚糖具有直接的抗癌作用，并可通过免疫调节途径抑制癌症增殖。全世界肺癌的死亡率令人震惊地不断上升；因此，治疗肺癌是当务之急。现在有许多研究人员致力于将β-葡聚糖作为治疗肺癌的一种方法。在目前的尝试中，我们回顾了 1991 年至 2016 年期间发表的关于β-葡聚糖对原发性和转移性肺癌的治疗作用的研究。
