Shimpo T, Gilliatt R W, Kennett R P, Allen P J
University Department of Clinical Neurology, Institute of Neurology, Queen Square, London, UK.
J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1625-32. doi: 10.1136/jnnp.50.12.1625.
Silk ligatures were tied round the sciatic nerve in guinea-pigs and left in place in order to produce persistent nerve constriction. Serial nerve conduction studies over the following 9 weeks showed a reduction in motor conduction velocity distal to the ligature. The presence of axonal atrophy in tibial nerve fibres in the leg was subsequently confirmed by histological studies. These changes were not seen in a second group of animals in which similar ligatures were tied but removed after 6 hours. When the ligatures were left in place, the animals developed local plantar nerve lesions in the sole of the foot on the affected side, which were thought to be due to pressure from the floor of the cage. Local pressure changes of varying severity were seen in the foot in all the constricted nerves, but were only occasionally found in control nerves from the opposite foot, or in nerves which had been constricted for a few hours by ligatures which were then removed. These results suggest that atrophic nerve fibres distal to a persistent constriction may be particularly sensitive to local pressure.
在豚鼠身上，丝线结扎坐骨神经并留置，以产生持续性神经压迫。在接下来的9周内进行的系列神经传导研究显示，结扎部位远端的运动传导速度降低。随后通过组织学研究证实了腿部胫神经纤维存在轴突萎缩。在第二组动物中，进行了类似的结扎，但6小时后移除，未观察到这些变化。当结扎线留置时，动物患侧足底出现局部足底神经病变，认为这是由于笼底压力所致。在所有受压神经的足部均可见不同程度的局部压力变化，但仅偶尔在对侧足部的对照神经或结扎数小时后移除结扎线的神经中发现。这些结果表明，持续性压迫远端的萎缩神经纤维可能对局部压力特别敏感。
