Knobloch K, Stetkiewicz J, Wrońska-Nofer T
Br J Ind Med. 1979 May;36(2):148-52. doi: 10.1136/oem.36.2.148.
Effects of carbon disulphide (CS2) on conduction velocity in sciatic and tibial nerve were investigated in rats exposed to CS2 vapour at concentrations of 0.9 mg/l or 1.6 mg/l of air for periods of 1.5, 3, 6, 9 and 12 months. The conduction velocity was measured on the day following each exposure period, and again, three and six months after the last day of exposure. The majority of exposed rats showed a reduction in conduction velocity on the day after exposure: the extent of this reduction was dependent on the CS2 concentration and the duration of exposure. Exposure for 1.5 months to 1.6 mg CS2/l produced temporary and fully reversible impairment of conduction velocity. Increased exposure to CS2 (3,6 or 9 months at 1.6 mg/l; 6 or 12 months at 0.9 mg/l CS2 in air) caused a reduction in velocity which was only partially reversible.
研究了二硫化碳（CS2）对暴露于浓度为0.9毫克/升或1.6毫克/升CS2蒸气中的大鼠坐骨神经和胫神经传导速度的影响，暴露时间为1.5、3、6、9和12个月。在每个暴露期后的第二天测量传导速度，并在暴露最后一天后的三个月和六个月再次测量。大多数暴露的大鼠在暴露后一天显示传导速度降低：这种降低的程度取决于CS2浓度和暴露持续时间。暴露于1.6毫克CS2/升1.5个月会导致传导速度暂时且完全可逆的损害。增加CS2暴露量（1.6毫克/升暴露3、6或9个月；空气中0.9毫克/升CS2暴露6或12个月）会导致速度降低，且仅部分可逆。
