Timson J
University Department of Medical Genetics, The Royal Infirmary, Manchester, UK.
Wilhelm Roux Arch Entwickl Mech Org. 1969 Jun;164(2):199-200. doi: 10.1007/BF00581999.
The addition of excess orotic acid to cultures of normal human lymphocytes stimulated with phytohaemagglutinin causes a reduction in the mitotic rate. It is suggested that this is caused by competition for the available 5-phosphoribosyl-1-pyrophosphate in the cell leading to a reduced purine synthesis. The significance of these results with regard to orotic aciduria is discussed.
向用植物血凝素刺激的正常人淋巴细胞培养物中添加过量乳清酸会导致有丝分裂率降低。有人认为，这是由于细胞内对可用的5-磷酸核糖-1-焦磷酸的竞争导致嘌呤合成减少所致。讨论了这些结果与乳清酸尿症的相关性。
