Bilich G L, Otmakhov V N, Nazarova L V
Arkh Anat Gistol Embriol. 1979 Jun;76(6):29-34.
The effect of orotic acid on pulmonary regeneration has been studied in mature rats after left-sided pneumonectomy. A complex morphometric analysis of the pulmonary parenchyma during the process of compensatory-hypertrophic rearrangement has been carried out; mitotic activity of cells in the interalveolar septae, peculiarities of DNA synthesis and those of enzymatic status in lymphocytes of the peripheral blood have been determined. As the investigations have demonstrated, the administration of orotic acid during the postoperative period contributes to a more complete regeneration of the lung volume, alveolar surface, results in formation of new alveoli, prevents the development of morphologic long-term decompensation following pneumonectomy. Activation of the alveolar cells proliferation and increased DNA synthesis are the main stimulating effects of orotic acid. Certain correlative connections are revealed between the course of pulmonary regenerative processes and the enzymic status of circulating lymphocytes.
已在成年大鼠左侧肺切除术后研究了乳清酸对肺再生的影响。对代偿性肥大重排过程中的肺实质进行了复杂的形态计量分析；测定了肺泡间隔细胞的有丝分裂活性、外周血淋巴细胞中DNA合成的特点以及酶状态的特点。研究表明，术后给予乳清酸有助于肺体积、肺泡表面更完全地再生，导致新肺泡形成，防止肺切除术后形态学长期失代偿的发展。肺泡细胞增殖的激活和DNA合成的增加是乳清酸的主要刺激作用。在肺再生过程的进程与循环淋巴细胞的酶状态之间发现了某些相关联系。
