Adler Paul N
Center for Pathobiology, University of California, 92717, Irvine, CA, USA.
Wilehm Roux Arch Dev Biol. 1978 Sep;185(3):271-292. doi: 10.1007/BF00848356.
Mutations of the bithorax complex result in segmental transformations in the thorax and abdomen ofDrosophila. The haltere discs from larvae homozygous forbx orpbx are transformed so that the discs contain cells that will produce wing cuticle as well as cells that produce haltere cuticle. The pattern regulation behavior of these discs has been examined. The fate maps of the two discs were established, and then the regulative behavior of a number of fragments from both types of mutant discs was established by culturing the fragments in vivo prior to metamorphosis. The most important conclusion from this work is that the cells producing, haltere cuticle and wing cuticle within the same disc share the same positional information and that they communicate during pattern regulation.
双胸复合体的突变会导致果蝇胸部和腹部的节段性转变。来自bx或pbx纯合幼虫的平衡棒盘发生转变，使得这些盘中含有将产生翅表皮的细胞以及产生平衡棒表皮的细胞。已经对这些盘的模式调控行为进行了研究。建立了两种盘的命运图谱，然后通过在变态前在体内培养这些片段，确定了来自两种突变盘的许多片段的调控行为。这项工作最重要的结论是，同一盘中产生平衡棒表皮和翅表皮的细胞共享相同的位置信息，并且它们在模式调控过程中进行通讯。
