Lampert F, Harbott J, Christiansen H
Abteilung Allgemeine Pädiatrie, Hämatologie und Onkologie, Universitäts-Kinderklinik Giessen.
Monatsschr Kinderheilkd. 1987 Dec;135(12):811-8.
Non-random, specific chromosome aberrations can be found by direct preparation in the karyotype of the malignant cell populations of the various leukemias and solid tumors in childhood. These chromosomal deletions in neuroblastoma, Wilms-Tumor, reticlassification and prognosis. There are mainly chromosomal deletions in neuroblastoma, Wilms-Tumor, retinoblastoma whereas translocations predominate in leukemias and lymphomas.
通过直接制备,可以在儿童各种白血病和实体瘤的恶性细胞群体的核型中发现非随机的、特定的染色体畸变。这些染色体缺失存在于神经母细胞瘤、肾母细胞瘤、视网膜母细胞瘤中,与分类和预后相关。神经母细胞瘤、肾母细胞瘤、视网膜母细胞瘤中主要存在染色体缺失,而白血病和淋巴瘤中则以易位为主。