De Braekeleer M
SOREP, University of Quebec, Chicoutimi, Canada.
Anticancer Res. 1988 Nov-Dec;8(6):1325-8.
Information on chromosomal structural rearrangements in leukemia and solid tumors was retracted from a computerized databank and the literature. A binomial test procedure was used to determine the statistical significance of the observed numbers of breaks. Some 131 human cancer-specific chromosomal structural rearrangements were also taken from the literature. The results showed that breakage and deletion occurred preferentially in bands known to contain proto-oncogenes, growth factor genes, receptor genes and differentiation genes. Therefore, chromosomal structural rearrangements could be used to find and map new genes involved in the genesis and/or progression of neoplasia.
有关白血病和实体瘤中染色体结构重排的信息已从计算机数据库和文献中撤回。采用二项式检验程序来确定观察到的断裂数的统计学意义。另外还从文献中选取了约131种人类癌症特异性染色体结构重排。结果表明，断裂和缺失优先发生在已知含有原癌基因、生长因子基因、受体基因和分化基因的条带中。因此，染色体结构重排可用于寻找和定位参与肿瘤发生和/或进展的新基因。
