The effects of histones H1, H5 and HMG proteins on cell division of cultured murine erythroleukemia cells.

作者信息

Richman Ronald, Gooderham Keith, Flickinger Reed

机构信息

Department of Biological Sciences, State University of New York, 14226, Buffalo, New York, USA.

MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, Scotland.

出版信息

Wilehm Roux Arch Dev Biol. 1984 Jan;194(1):53-55. doi: 10.1007/BF00848955.

In the present study the effect of histones H1 and H5, and the nonhistone chromatin proteins HMG 1, 2, 14 and 17 (the high mobility group proteins), as well as the acidic peptide fragments of HMG 1 and 2 and polyglutamate, on cell division and differentation of cultured murine erythroleukemia (Friend) cells has been investigated. It was found that histones H1 and H5, the acidic peptide fragments of HMG 1 and 2, HMG 14 and 17 and sodium polyglutamate stimulated cell division at a concentration of 10 μg/ml. None of the H1, H5 or HMG protein preparations induced hemoglobin synthesis, as judged by benzidine staining.