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黑腹果蝇的同源异型基因性梳减少与双胸（或三胸）基因调控因子之间的遗传相互作用。

Genetic interaction between homoeotic Sex combs reduced and Regulator of bithorax (or trithorax) genes of Drosophila melanogaster.

作者信息

Sato Takashi

机构信息

Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi, 186, Tokyo, Japan.

出版信息

Rouxs Arch Dev Biol. 1988 Dec;197(7):435-440. doi: 10.1007/BF00398995.

DOI:10.1007/BF00398995
PMID:28305751
Abstract

Regulator of bithorax (Rg-bx), or trithorax (trx) lethal larvae occasionally show a homoeotic transformation of the dorsal prothorax to mesothoracic structures. This transformation suggests a reduced activity of the Sex combs reduced (Scr) gene on the basis of gene dosage studies, as well as enhanced expression of the phenotypes of the weak Scr alleles in Rg-bx larvae. Morphological observations of adult flies doubly heterozygous for Rg-bx and Scr mutations also suggest the enhancement of an aspect of Scr adult phenotypes. I conclude that the Rg-bx gene function is required for the optimal expression of the Scr gene in larval and imaginai cells.

摘要

双胸调节基因（Rg-bx），即三胸基因（trx），其致死幼虫偶尔会出现前胸背板向中胸结构的同源异型转化。基于基因剂量研究，这种转化表明性别梳减少基因（Scr）的活性降低，同时也表明Rg-bx幼虫中弱Scr等位基因的表型表达增强。对Rg-bx和Scr突变的双杂合成年果蝇的形态学观察也表明Scr成年表型的一个方面得到了增强。我得出结论，Rg-bx基因功能是Scr基因在幼虫和成虫细胞中最佳表达所必需的。

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1
Genetic interaction between homoeotic Sex combs reduced and Regulator of bithorax (or trithorax) genes of Drosophila melanogaster.黑腹果蝇的同源异型基因性梳减少与双胸（或三胸）基因调控因子之间的遗传相互作用。
Rouxs Arch Dev Biol. 1988 Dec;197(7):435-440. doi: 10.1007/BF00398995.
2
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Genetics. 1987 Jul;116(3):389-98. doi: 10.1093/genetics/116.3.389.
3
Differential expression of bithorax complex genes in the absence of the extra sex combs and trithorax genes.双胸复合体基因在缺失额外的触须和三胸复合体基因时的差异表达。
Nature. 1983;306(5943):591-3. doi: 10.1038/306591a0.
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本文引用的文献

1
Trithorax: A new homoeotic mutation ofDrosophila melanogaster : II. The role oftrx after embryogenesis.三体胸：果蝇的一种新的同源异型突变：II.胚胎发生后trx的作用
Wilehm Roux Arch Dev Biol. 1981 Nov;190(6):365-369. doi: 10.1007/BF00863275.
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Genes involved in the activation of the bithorax complex ofDrosophila.参与果蝇双胸复合体激活的基因。
Wilehm Roux Arch Dev Biol. 1981 Nov;190(6):339-350. doi: 10.1007/BF00863271.
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Establishment of compartments in the developing leg imaginal discs ofDrosophila melanogaster.在黑腹果蝇发育中的腿部成虫盘内隔室的建立。
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Differential expression of bithorax complex genes in the absence of the extra sex combs and trithorax genes.双胸复合体基因在缺失额外的触须和三胸复合体基因时的差异表达。
Nature. 1983;306(5943):591-3. doi: 10.1038/306591a0.
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Genetic Analysis of the Antennapedia Gene Complex (Ant-C) and Adjacent Chromosomal Regions of DROSOPHILA MELANOGASTER. II. Polytene Chromosome Segments 84A-84B1,2.黑腹果蝇触角足基因复合体（Ant-C）及其邻近染色体区域的遗传分析。二、多线染色体 84A-84B1、2 区。
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Genetic Analysis of the Antennapedia Gene Complex (Ant-C) and Adjacent Chromosomal Regions of DROSOPHILA MELANOGASTER. I. Polytene Chromosome Segments 84b-D.黑腹果蝇触角足基因复合体（Ant-C）及其相邻染色体区域的遗传分析。I. 多线染色体节段 84b-D。
Genetics. 1980 Jun;95(2):367-81. doi: 10.1093/genetics/95.2.367.
7
Cytogenetic Analysis of Chromosome 3 in DROSOPHILA MELANOGASTER: Isolation and Characterization of Four New Alleles of the Proboscipedia (pb) Locus.黑腹果蝇 3 号染色体的细胞遗传学分析：触角足（pb）基因座的四个新等位基因的分离和鉴定。
Genetics. 1978 Nov;90(3):579-96. doi: 10.1093/genetics/90.3.579.
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Homoeosis in Drosophila: The Lethal Syndrome of the Regulator of bithorax (or trithorax) Locus and Its Interaction with Other Homoeotic Loci.果蝇中的同形异位现象：调控双胸（或三胸）基因座的致死综合征及其与其他同形异位基因座的相互作用。
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