Capdevila M P, García-Bellido A
Centro de Biologia Molecular Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid Canto Blanco, Madrid-34, Spain.
Wilehm Roux Arch Dev Biol. 1981 Nov;190(6):339-350. doi: 10.1007/BF00863271.
We have studied the genetic properties and developmental effects of several mutations, in eight different loci, which alter the specification of embryonic segments. All of the changes are related to the transformations caused by mutants of the bithorax complex.Several properties: the interactions of these mutants with different mutants of the bithorax complex, the interactions between themselves, the effect of changing dosages of their wildtype alleles and their response to ether induction of phenocopies permit one to distinguish between those mutations which affect activation of the bithorax genes in early embryogenesis and those which affect expression of the bithorax genes during development. This paper deals mainly with the Rg-bx locus and its interactions with other loci which affect segment specification.In particular two loci show genetic and developmental characteristics which seem to conform to those expected for a repressor coding gene (Polycomb) and for an inducer synthesizing gene (Rg-bx) active in a negative control system of the genes in the bithorax complex. A model for the interaction of the wildtype products of these genes to determine the segmental characteristics of both the thorax and abdomen is proposed.
我们研究了八个不同基因座中的几种突变的遗传特性和发育效应，这些突变改变了胚胎节段的特化。所有这些变化都与双胸复合体突变体引起的转化有关。几种特性：这些突变体与双胸复合体不同突变体的相互作用、它们彼此之间的相互作用、改变其野生型等位基因剂量的效应以及它们对乙醚诱导拟表型的反应，使人们能够区分那些在胚胎发育早期影响双胸基因激活的突变和那些在发育过程中影响双胸基因表达的突变。本文主要探讨Rg-bx基因座及其与其他影响节段特化的基因座的相互作用。特别是有两个基因座表现出的遗传和发育特征，似乎符合双胸复合体中一个阻遏物编码基因（多梳基因）和一个在双胸复合体基因的负控制系统中起作用的诱导物合成基因（Rg-bx）所预期的特征。我们提出了一个关于这些基因的野生型产物相互作用以确定胸部和腹部节段特征的模型。
