人类转座子样元件在一个偏好的靶位点插入：逆转录病毒介导过程的证据。
Human transposon-like elements insert at a preferred target site: evidence for a retrovirally mediated process.
作者信息
Deka N, Willard C R, Wong E, Schmid C W
机构信息
Department of Chemistry, University of California, Davis 95616.
出版信息
Nucleic Acids Res. 1988 Feb 11;16(3):1143-51. doi: 10.1093/nar/16.3.1143.
Abstract
Members of the human transposon-like family of repetitive sequences (called THE 1 repeats) like many other repetitive DNA sequences are flanked by short direct repeats. Comparison of the base sequences of twelve examples of these flanking direct repeats indicates that THE 1 repeats insert into a preferred genomic target site. In one case, we have identified the sequence of an empty site into which a THE 1 element inserted. The sequence of this empty site and sequences of truncated THE 1 LTRs are consistent with a retroviral mechanism for the insertion of THE 1 elements. Truncated transposon structures illustrate for the first time that intermediate structures of retrotransposition may also be integrated into the genome.
摘要
人类重复序列中转座子样家族（称为THE 1重复序列）的成员，与许多其他重复DNA序列一样，两侧都有短的直接重复序列。对这些侧翼直接重复序列的12个实例的碱基序列进行比较表明，THE 1重复序列插入到一个优先的基因组靶位点。在一个案例中，我们确定了一个THE 1元件插入其中的空位序列。这个空位的序列和截短的THE 1长末端重复序列（LTRs）的序列与THE 1元件插入的逆转录病毒机制一致。截短的转座子结构首次表明，逆转座的中间结构也可能整合到基因组中。
相似文献
1
Human transposon-like elements insert at a preferred target site: evidence for a retrovirally mediated process.人类转座子样元件在一个偏好的靶位点插入：逆转录病毒介导过程的证据。
Nucleic Acids Res. 1988 Feb 11;16(3):1143-51. doi: 10.1093/nar/16.3.1143.
2
Evidence that a major class of mouse endogenous long terminal repeats (LTRs) resulted from recombination between exogenous retroviral LTRs and similar LTR-like elements (LTR-IS).有证据表明，一类主要的小鼠内源性长末端重复序列（LTRs）是由外源性逆转录病毒LTRs与类似的LTR样元件（LTR-IS）之间的重组产生的。
Proc Natl Acad Sci U S A. 1984 Nov;81(21):6696-700. doi: 10.1073/pnas.81.21.6696.
3
Nucleotide sequence analysis of avian retroviruses: structural similarities with transposable elements.禽逆转录病毒的核苷酸序列分析：与转座元件的结构相似性
Fed Proc. 1982 Aug;41(10):2659-61.
4
A transposon-like element in human DNA.人类DNA中的一种类转座子元件。
Nature. 1985;316(6026):359-61. doi: 10.1038/316359a0.
5
Single copy sequences in galago DNA resemble a repetitive human retrotransposon-like family.婴猴DNA中的单拷贝序列类似于一个重复的人类逆转录转座子样家族。
J Mol Evol. 1990 Aug;31(2):92-100. doi: 10.1007/BF02109478.
6
A transposon-like sequence with short terminal inverted repeats in the nuclear genome of Chlamydomonas reinhardtii.莱茵衣藻核基因组中一个具有短末端反向重复序列的转座子样序列。
Plant Mol Biol. 1995 Jun;28(3):437-42. doi: 10.1007/BF00020392.
7
Family of middle repetitive DNA sequences in the mouse genome with structural features of solitary retroviral long terminal repeats.小鼠基因组中具有单独逆转录病毒长末端重复序列结构特征的中等重复DNA序列家族。
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3327-30. doi: 10.1073/pnas.80.11.3327.
8
Integration site preferences of the Alu family and similar repetitive DNA sequences.Alu家族及类似重复DNA序列的整合位点偏好性
Nucleic Acids Res. 1985 Dec 20;13(24):8939-54. doi: 10.1093/nar/13.24.8939.
9
Insertion of an intermediate repetitive sequence into a sea urchin histone-gene spacer.一个中间重复序列插入海胆组蛋白基因间隔区。
J Mol Evol. 1987;24(4):346-56. doi: 10.1007/BF02134133.
10
Simple human DNA-repeats associated with genomic hypervariability, flanking the genomic retroposons and similar to retroviral sites.简单的人类DNA重复序列与基因组高变异性相关，位于基因组逆转座子两侧，且类似于逆转录病毒位点。
Nucleic Acids Res. 1990 Apr 11;18(7):1879-85. doi: 10.1093/nar/18.7.1879.
引用本文的文献
1
Identification of a new, abundant superfamily of mammalian LTR-transposons.鉴定出一种新的、丰富的哺乳动物长末端重复序列转座子超家族。
Nucleic Acids Res. 1993 Apr 25;21(8):1863-72. doi: 10.1093/nar/21.8.1863.
2
The genome of the THE I human transposable repetitive elements is composed of a basic motif homologous to an ancestral immunoglobulin gene sequence.THE I人类转座重复元件的基因组由与祖先免疫球蛋白基因序列同源的基本基序组成。
Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):7967-9. doi: 10.1073/pnas.91.17.7967.
3
Analysis of yeast retrotransposon Ty insertions at the CAN1 locus.对CAN1基因座处酵母逆转录转座子Ty插入的分析。
Genetics. 1989 Dec;123(4):655-65. doi: 10.1093/genetics/123.4.655.
4
Recombination mediates production of an extrachromosomal circular DNA containing a transposon-like human element, THE-1.重组介导了一种含有类转座子人类元件THE-1的染色体外环状DNA的产生。
Nucleic Acids Res. 1989 Oct 25;17(20):8327-41. doi: 10.1093/nar/17.20.8327.
5
Single copy sequences in galago DNA resemble a repetitive human retrotransposon-like family.婴猴DNA中的单拷贝序列类似于一个重复的人类逆转录转座子样家族。
J Mol Evol. 1990 Aug;31(2):92-100. doi: 10.1007/BF02109478.
本文引用的文献
1
Structure, variation and synthesis of retrovirus long terminal repeat.逆转录病毒长末端重复序列的结构、变异与合成
Cell. 1981 Nov;27(1 Pt 2):1-3. doi: 10.1016/0092-8674(81)90353-6.
2
Circles with two tandem LTRs are precursors to integrated retrovirus DNA.带有两个串联长末端重复序列的环状结构是整合型逆转录病毒DNA的前体。
Cell. 1984 Mar;36(3):673-9. doi: 10.1016/0092-8674(84)90347-7.
3
Non-Alu family interspersed repeats in human DNA and their transcriptional activity.人类DNA中的非Alu家族散布重复序列及其转录活性。
Nucleic Acids Res. 1984 Mar 26;12(6):2669-90. doi: 10.1093/nar/12.6.2669.
4
Preferential integration of yeast transposable element Ty into a promoter region.酵母转座因子Ty优先整合到启动子区域。
Nature. 1984;307(5949):386-8. doi: 10.1038/307386a0.
5
Intracisternal A-particle genes as movable elements in the mouse genome.脑池内A颗粒基因作为小鼠基因组中的可移动元件。
Proc Natl Acad Sci U S A. 1983 Apr;80(7):1992-6. doi: 10.1073/pnas.80.7.1992.
6
The 5' termini of RNAs encoded by the transposable element copia.转座因子copia编码的RNA的5'末端。
Nucleic Acids Res. 1981 Dec 11;9(23):6279-91. doi: 10.1093/nar/9.23.6279.
7
A system for shotgun DNA sequencing.一种用于鸟枪法DNA测序的系统。
Nucleic Acids Res. 1981 Jan 24;9(2):309-21. doi: 10.1093/nar/9.2.309.
8
RNA from the yeast transposable element Ty1 has both ends in the direct repeats, a structure similar to retrovirus RNA.来自酵母转座因子Ty1的RNA在直接重复序列中都有两端，这种结构类似于逆转录病毒RNA。
Proc Natl Acad Sci U S A. 1983 May;80(9):2432-6. doi: 10.1073/pnas.80.9.2432.
9
Form and function of retroviral proviruses.逆转录病毒前病毒的形式与功能。
Science. 1982 May 21;216(4548):812-20. doi: 10.1126/science.6177038.
10
Sequence-specific insertion of the Drosophila transposable genetic element 17.6.果蝇转座遗传元件17.6的序列特异性插入
Nature. 1984;310(5975):332-3. doi: 10.1038/310332a0.
Zotero 插件