Klein Thomas, Campos-Ortega Jose A
Institut fur Entwicklungsbiologie, Universität zu Köln, Gyrhofstraße 17, W-5000, Köln 41, Federal Republic of Germany.
Rouxs Arch Dev Biol. 1992 Dec;202(1):49-60. doi: 10.1007/BF00364596.
We have screened for dominant enhancers and suppressors of the wing phenotype associated with two Delta alleles: Dl , an amorphic allele, and Dl , an antimorphic allele. The interactions of some of the modifiers with Delta are due to haplo-insufficient expression of the corresponding genes. Although not explicitly shown for the remaining cases, we assume that haploin-sufficiency is also the basis for the relationships of these genes to Delta, since no allele specific interactions were observed. The modifiers found define 22 genes with pleiotropic expression, which can be classified into two groups: genes required for wing vein pattern formation and for neurogenesis, and genes which are not required for neurogenesis. Among the genes of the first group, Hairless and Star were previously known to participate in neural development. One further modifier was found which may correspond to a new neurogenic gene. The second group of genes is larger and includes already known loci, e.g., Plexate, blistered, plexus, etc, as well as other previously unidentified genes, which function during wing morphogenesis.
我们筛选了与两个Delta等位基因相关的翅表型的显性增强子和抑制子：无义等位基因Dl和反义等位基因Dl。一些修饰因子与Delta的相互作用是由于相应基因的单倍体不足表达。尽管其余情况未明确显示，但我们假设单倍体不足也是这些基因与Delta关系的基础，因为未观察到等位基因特异性相互作用。发现的修饰因子定义了22个具有多效性表达的基因，可分为两组：翅脉模式形成和神经发生所需的基因，以及神经发生不需要的基因。在第一组基因中，无毛基因和星状基因以前已知参与神经发育。还发现了一个可能对应于新神经发生基因的修饰因子。第二组基因较多，包括已知位点，如丛状基因、水泡基因、神经丛基因等，以及其他以前未鉴定的基因，它们在翅形态发生过程中发挥作用。
