Dietrich U, Campos-Ortega J A
J Neurogenet. 1984 Dec;1(4):315-32. doi: 10.3109/01677068409107094.
Six zygotically expressed genomic loci of Drosophila melanogaster, N, bib, mam, neu, Dl and E (spl), have previously been found to be involved in the commitment of ectodermal cells as neuroblasts. We have studied phenotypes induced by various mutant alleles at these 6 loci in imaginal epidermal cells, in order to assess possible implications of the genes in functions other than early neurogenesis. When homozygous, any of these mutations except bib affected the development of bristles and compound eye in various ways. These range from cell death to the production of additional bristles and several defects in ommatidial patterning, depending on the allele used. In contrast clones of bib homozygous cells exhibited wild-type phenotypes. The differences found in the expression of the neurogenic genes are discussed with respect to a hypothesis on the genetic control of neurogenesis.
黑腹果蝇的六个合子表达基因组位点，即N、bib、mam、neu、Dl和E（spl），此前已被发现参与外胚层细胞向神经母细胞的分化。我们研究了这6个位点上各种突变等位基因在成虫表皮细胞中诱导的表型，以评估这些基因在早期神经发生以外的功能中可能产生的影响。当这些突变纯合时，除bib外，任何一个突变都会以各种方式影响刚毛和复眼的发育。根据所使用的等位基因不同，这些影响范围从细胞死亡到额外刚毛的产生以及小眼模式的几种缺陷。相比之下，bib纯合细胞的克隆表现出野生型表型。我们根据神经发生的遗传控制假说，讨论了神经发生基因表达中发现的差异。
