Shepard S B, Broverman S A, Muskavitch M A
Department of Biology, Indiana University, Bloomington 47405.
Genetics. 1989 Jun;122(2):429-38. doi: 10.1093/genetics/122.2.429.
A dramatic example of a phenotypic interaction that involves neurogenic loci during Drosophila imaginal development is the synergistic impact of split (spl), a recessive allele of the Notch locus, and E(spl)D, a dominant gain-of-function allele of the Enhancer of split locus, on morphogenesis of the compound eye. Screens for mutations that relieve the enhancing effect of E(spl)D on spl have yielded three classes of mutations: intragenic revertants of the E(spl)D allele, extragenic suppressors that are allelic to the neurogenic gene Delta (Dl) and unlinked extragenic modifiers. Analysis of the suppression of the spl-E(spl)D interaction by various Dl alleles indicates that this modification is sensitive to the dosage of the Dl locus. This tripartite interaction illustrates the combinatorial action of N, Dl and E(spl) during imaginal development.
在果蝇成虫发育过程中，涉及神经源基因座的表型相互作用的一个显著例子是Notch基因座的隐性等位基因split（spl）和split增强子基因座的显性功能获得性等位基因E(spl)D对复眼形态发生的协同影响。筛选可缓解E(spl)D对spl增强作用的突变，得到了三类突变：E(spl)D等位基因的基因内回复突变体、与神经源基因Delta（Dl）等位的基因外抑制子以及不连锁的基因外修饰因子。对各种Dl等位基因对spl-E(spl)D相互作用的抑制作用分析表明，这种修饰对Dl基因座的剂量敏感。这种三方相互作用说明了N、Dl和E(spl)在成虫发育过程中的组合作用。
