Vetulani J, Marona-Lewicka D, Michaluk J, Antkiewicz-Michaluk L
Institute of Pharmacology, Polish Acaodemy of Sciences, Kraków.
Pol J Pharmacol Pharm. 1987 May-Jun;39(3):273-81.
The exploratory and basal locomotor activities were tested in four groups of Albino-Swiss mice twice, at a 4-5 day interval, to investigate the variability of responses and correlation between the exploratory and basal locomotor activity, and their stability in individual animals. We have found that there exists only a weak correlation between the exploratory and basal locomotor activities. The repetition of tests results in a slight but significant depression of the exploratory, but not of the basal locomotor activity. The correlation between individual performances in two subsequent tests is generally low, regarding both the exploratory and the basal locomotor activity. There are no differences in the density of cerebral alpha 1-adrenoceptors between mice exhibiting extremely different exploratory or basal locomotor activities. The results suggest that preselection of mice for the tests involving locomotor activity in attempt to reduce the variability of results is pointless.
对四组白化瑞士小鼠进行了两次探索性和基础运动活动测试，间隔4 - 5天，以研究反应的变异性、探索性与基础运动活动之间的相关性以及它们在个体动物中的稳定性。我们发现探索性和基础运动活动之间仅存在微弱的相关性。重复测试会导致探索性运动活动略有但显著的降低，但基础运动活动不受影响。在两次连续测试中，个体表现之间的相关性通常较低，无论是探索性还是基础运动活动。在表现出极不相同的探索性或基础运动活动的小鼠之间，脑α1 - 肾上腺素能受体的密度没有差异。结果表明，试图通过预先选择小鼠来进行涉及运动活动的测试以减少结果的变异性是没有意义的。
