Yildiz Tasci Yelda, Gürdal Canan, Sarac Ozge, Onusever Aykut
a Ataturk Training and Research Hospital , Department of Ophthalmology , Ankara , Turkey.
b Diskapi Yildirim Beyazit Training and Research Hospital , Department of Ophthalmology , Ankara , Turkey.
Curr Eye Res. 2017 Jul;42(7):976-981. doi: 10.1080/02713683.2016.1276194. Epub 2017 Mar 17.
To evaluate the effects of three different silicone hydrogel contact lenses (SHCL), (balafilcon A, senofilcon A, and comfilcon A) on tear function tests, corneal thickness, and ocular surface cytology in first time contact lens users.
In this prospective study, 120 eyes of 60 subjects were evaluated. Balafilcon A users were designated as group 1, senofilcon A users as group 2, and comfilcon A users as group 3. In all cases, before and after 6 months of contact lens wear, ocular surface disease index score (OSDI), tear breakup time (TBUT), Schirmer 1 test, central corneal thickness (CCT), central corneal epithelium thickness (CCET), and conjunctival impression cytology samples were evaluated.
In group 1, 40 eyes of the 20 patients, in group 2, 40 eyes of the 20 patients, and in group 3, 40 eyes of the 20 patients were evaluated. The mean OSDI scores did not differ between the three groups after contact lens wear (p > 0.05). In group 1 and group 2, significant decrease was found in the mean TBUT 6 months after contact lens wear (p = 0.04, p < 0.001, respectively). In group 3, after 6 months of contact lens wear, the mean Schirmer 1 tear test was decreased significantly (p = 0.021). In all 3 groups, no significant change was observed in the mean CCT and CCET after contact lens wear (p > 0.05). After 6 months, the morphological changes in temporal and superior conjunctival epithelial cells were found to be significant in all groups (p < 0.001).
Six months after SHCL wear, marked morphological changes occurred in the conjunctival epithelium. Tear function tests were also affected, while corneal thickness did not show any significant difference.
评估三种不同的硅水凝胶隐形眼镜（SHCL，即百超菲康A、森弗菲康A和康菲康A）对初次佩戴隐形眼镜者泪液功能测试、角膜厚度和眼表细胞学的影响。
在这项前瞻性研究中，对60名受试者的120只眼睛进行了评估。使用百超菲康A的受试者被指定为第1组，使用森弗菲康A的受试者为第2组，使用康菲康A的受试者为第3组。在所有情况下，在佩戴隐形眼镜6个月前后，评估眼表疾病指数评分（OSDI）、泪膜破裂时间（TBUT）、Schirmer 1试验、中央角膜厚度（CCT）、中央角膜上皮厚度（CCET）以及结膜印片细胞学样本。
在第1组中，对20名患者的40只眼睛进行了评估，在第2组中，对20名患者的40只眼睛进行了评估，在第3组中，对20名患者的40只眼睛进行了评估。佩戴隐形眼镜后，三组之间的平均OSDI评分没有差异（p>0.05）。在第1组和第2组中，佩戴隐形眼镜6个月后平均TBUT显著降低（分别为p = 0.04，p < 0.001）。在第3组中，佩戴隐形眼镜6个月后，平均Schirmer 1泪液试验显著降低（p = 0.021）。在所有3组中，佩戴隐形眼镜后平均CCT和CCET均未观察到显著变化（p>0.05）。6个月后，发现所有组颞侧和上方结膜上皮细胞的形态变化均显著（p < 0.001）。
佩戴SHCL 6个月后，结膜上皮出现明显的形态变化。泪液功能测试也受到影响，而角膜厚度没有显示出任何显著差异。
