一次捕获一个 Sirtuin-2 中间体结构。
Catching Sirtuin-2 Intermediates One Structure at the Time.
机构信息
Department of Biomedical Research, National Jewish Health, 1400 Jackson St, Denver, CO 80206, USA.
State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China.
出版信息
Cell Chem Biol. 2017 Mar 16;24(3):248-249. doi: 10.1016/j.chembiol.2017.03.004.
Sirtuins are a large enzyme family involved in installing and removing post-translational modifications involving lysine side chains. These enzymes have been of intense research interest and we now understand many details of their mechanism, although later steps of the deacetylase activity have remained a mystery. In this issue of Cell Chemical Biology, Wang et al. (2017) capture a late intermediate of SIRT2 catalysis and describe its structure.
去乙酰化酶是一类参与赖氨酸侧链翻译后修饰的酶家族，Sirtuins 就是其中之一。尽管去乙酰化酶的后续步骤仍然是一个谜，但这些酶已成为研究热点，我们现在已经了解了它们的许多机制细节。在本期《细胞化学生物学》中，Wang 等人（2017）捕获了 SIRT2 催化的晚期中间产物，并描述了其结构。
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