PTEN-PARKIN 轴：癌症与神经退行性变的交汇点。
The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration.
机构信息
Oncology R&D Group, Pfizer Worldwide Research & Development, 10646/CB4, Science Center Drive, San Diego, CA 92121, USA.
Oncology R&D Group, Pfizer Worldwide Research & Development, 10646/CB4, Science Center Drive, San Diego, CA 92121, USA.
出版信息
Mol Cell. 2017 Mar 16;65(6):959-960. doi: 10.1016/j.molcel.2017.02.030.
PMID:28306509
Abstract
The PARK2 gene encodes an ubiquitin E3 ligase that is involved in mitochondrial homeostasis and linked to Parkinson's disease. In this issue, Gupta et al. (2017) demonstrate that PARK2 expression is frequently reduced in human cancers and that this alteration leads to dysregulated PI3K signaling.
摘要
PARK2 基因编码一种泛素 E3 连接酶，参与线粒体动态平衡，并与帕金森病有关。在本期中，Gupta 等人（2017）表明，PARK2 的表达在人类癌症中经常降低，这种改变导致 PI3K 信号的失调。
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