Taiwan International Graduate Program in Interdisciplinary Neuroscience, National Yang-Ming University and Academia Sinica, Taipei 11529, Taiwan.
Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.
Int J Mol Sci. 2017 Sep 13;18(9):1963. doi: 10.3390/ijms18091963.
Protein homeostasis or proteostasis is a fundamental cellular property that encompasses the dynamic balancing of processes in the proteostasis network (PN). Such processes include protein synthesis, folding, and degradation in both non-stressed and stressful conditions. The role of the PN in neurodegenerative disease is well-documented, where it is known to respond to changes in protein folding states or toxic gain-of-function protein aggregation. Dual-specificity phosphatases have recently emerged as important participants in maintaining balance within the PN, acting through modulation of cellular signaling pathways that are involved in neurodegeneration. In this review, we will summarize recent findings describing the roles of dual-specificity phosphatases in neurodegeneration and offer perspectives on future therapeutic directions.
蛋白质动态平衡或蛋白质稳态是一种基本的细胞特性，涵盖了蛋白质稳态网络 (PN) 中各种过程的动态平衡。这些过程包括在非应激和应激条件下的蛋白质合成、折叠和降解。PN 在神经退行性疾病中的作用已有充分的文献记载，已知其对蛋白质折叠状态的变化或有毒功能获得性蛋白聚集的反应。双特异性磷酸酶最近已成为维持 PN 内平衡的重要参与者，通过调节参与神经退行性变的细胞信号通路来发挥作用。在这篇综述中，我们将总结描述双特异性磷酸酶在神经退行性变中的作用的最新发现，并对未来的治疗方向提出看法。
