Department of Cell Physiology and Metabolism, University of Geneva, 1, rue Michel-Servet, 1211 Geneva 4, Switzerland.
Department of Cell Physiology and Metabolism, University of Geneva, 1, rue Michel-Servet, 1211 Geneva 4, Switzerland.
Mol Cell. 2017 Mar 16;65(6):961-962. doi: 10.1016/j.molcel.2017.02.029.
Dong et al. (2017) establish how the mitochondrial Ca uniporter (MCU) integrates Ca and oxidative stress signals by identifying a cysteine residue that controls MCU channel activity, a mechanism causing mitochondrial Ca overload and cell death during oxidative stress.
董等人（2017 年）通过确定一个半胱氨酸残基来识别控制 MCU 通道活性的机制，从而建立了线粒体钙单向转运体（MCU）如何整合钙和氧化应激信号，该机制在氧化应激过程中导致线粒体钙超载和细胞死亡。
