Ramos Flores Christian, Echeagaray Ernesto, Castañeda Guadalupe, Vargas Maria de Lourdes, Montes-González Raúl, Luna Susana, Díaz Laura, Torres Oscar
Departamento de Epidemiología, Unidad de Medicina Familiar 168, Instituto Mexicano del Seguro Social, Tepatitlán, Jalisco, México. Address: Avenida Patria 3000, Edificio 23, Departamento 6, Colonia Lagos del Country, Zapopan, Jalisco, México. Email:
Departamento de Infectología, Centro Médico Nacional de Occidente, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Guadalajara Jalisco, México.
Medwave. 2017 Mar 15;17(2):e6886. doi: 10.5867/medwave.2017.02.6886.
Most blood transfusions occur in female patients. The introduction of serologic screening practices by blood banks reduced the transfusion-related rate of infection with hepatitis C virus (HCV). In Mexico patients with pre-1994 transfusion history are at high risk of being detected with HCV infection. We aimed at establishing an interrelationship between two variables: pre-1994 transfusion history and rate of infection in women treated in the Guadalajara Metropolitan Area hospitals, in Mexico.
Analytical observational case-control study which included both non-infected women and patients diagnosed with hepatitis C virus infection, in whom the pre-1994 transfusion history was determined. The cases were 150 women with confirmed hepatitis C virus serologic diagnosis. The controls were 150 women whose hepatitis C virus-detection serologic tests had yielded negative results.
An odds ratio of 9.07 (95% CI: 5.37 – 15.3; p< 0.001) was found where the rate of infection for the case group was 0.72 while the control group had a ratio of 0.22; population attributable risk (PAR) was 0.64 (95% CI: 0.53 – 0.73), while etiologic fraction was 0.88 (95% CI: 0.81 – 0.93).
Among women, having been exposed to pre-1994 blood transfusion means a risk 9.07 times higher than not being exposed to blood transfusion in the same time frame.
大多数输血发生在女性患者身上。血库引入血清学筛查措施降低了丙型肝炎病毒（HCV）输血相关感染率。在墨西哥，有1994年前输血史的患者感染HCV的风险很高。我们旨在确定两个变量之间的相互关系：1994年前的输血史与墨西哥瓜达拉哈拉大都会区医院接受治疗的女性的感染率。
分析性观察病例对照研究，纳入未感染女性和被诊断为丙型肝炎病毒感染的患者，确定其1994年前的输血史。病例为150名丙型肝炎病毒血清学诊断确诊的女性。对照为150名丙型肝炎病毒检测血清学试验结果为阴性的女性。
发现比值比为9.07（95%置信区间：5.37 - 15.3；p < 0.001），病例组感染率为0.72，而对照组为0.22；人群归因风险（PAR）为0.64（95%置信区间：0.53 - 0.73），病因分数为0.88（95%置信区间：0.81 - 0.93）。
在女性中，有1994年前输血史意味着感染风险比同期未输血者高9.07倍。
