Yamahara M, Fujito T, Ishikawa T, Shimosato T, Yokozaki H, Yasui W, Tahara E
Department of Oral and Maxillo-facial Surgery, Hiroshima University School of Dentistry, Japan.
Virchows Arch A Pathol Anat Histopathol. 1988;412(4):301-6. doi: 10.1007/BF00750255.
The phenotypic expression of the human epidermal growth factor (EGF) was investigated immunohistochemically in human foetal submandibular glands from the 5th to 10th month of gestation, adult normal submandibular glands and 48 cases of pleomorphic adenomas. In foetal submandibular glands, both the terminal buds and primary ducts at the intermediate stage of gestation were positive for EGF, and in particular, the outer layer cells of primary ducts showed strong EGF-immunoreactivity. EGF-positive cells decreased as the gestational stage advanced and only ductal cells were weakly positive for EGF at the terminal stage of gestation. In the adult normal submandibular gland, weak immunoreactivity for EGF was restricted to ductal cells. However, 41 (86%) of the 48 pleomorphic adenomas had EGF-positive cells which were distributed among the ductal, chondroid and myxoid portion. No EGF-immunoreactivity was detected in the solid portion of pleomorphic adenomas. These results suggest that EGF may play an important role in the growth and differentiation of foetal cells as well as the proliferation of tumour cells in pleomorphic adenomas.
采用免疫组织化学方法，对妊娠第5至10个月的人胎儿下颌下腺、成人正常下颌下腺及48例多形性腺瘤中人类表皮生长因子（EGF）的表型表达进行了研究。在胎儿下颌下腺中，妊娠中期的终末芽和初级导管均呈EGF阳性，尤其是初级导管的外层细胞显示出强烈的EGF免疫反应性。随着妊娠阶段的推进，EGF阳性细胞减少，在妊娠末期仅导管细胞呈微弱的EGF阳性。在成人正常下颌下腺中，EGF的微弱免疫反应性仅限于导管细胞。然而，48例多形性腺瘤中有41例（86%）存在EGF阳性细胞，这些细胞分布于导管、软骨样和黏液样部分。在多形性腺瘤的实性部分未检测到EGF免疫反应性。这些结果表明，EGF可能在胎儿细胞的生长和分化以及多形性腺瘤中肿瘤细胞的增殖中发挥重要作用。
