Kusafuka K, Yamaguchi A, Kayano T, Takemura T
Department of Pathology, Japanese Red Cross Medical Center, Tokyo.
J Oral Pathol Med. 1998 Aug;27(7):287-92. doi: 10.1111/j.1600-0714.1998.tb01958.x.
Basic and acidic fibroblast growth factors (bFGF and aFGF) are heparin-binding growth factors, and promote fibrogenesis and angiogenesis. We investigated the immunohistochemical localization of bFGFE, aFGF, and FGF receptor-1 in pleomorphic adenomas. In the normal salivary glands, bFGF was localized in the basement membranes of intercalated ducts, acini and basal cells of the excretory ducts, while aFGF was localized focally in the intercalated ductal cells and basal cells of the excretory ducts. In pleomorphic adenomas, bFGF was immunolocalized in the basement membranes around the solid nests of myoepithelial cells, around the neoplastic myoepithelial cells in the myxoid areas, and in the lacuna cells in the chondroid areas. In contrast, chondroid areas exhibited no immunoreactivity with aFGE. Positive signals for aFGF were localized in luminal cells of the tubuloglandular structures in pleomorphic adenomas. FGF receptor-1 immunolocalized in the lacuna cells and myoepithelial cells in the solid and myxoid areas. These observations suggest that bFGF and FGF receptor-1 produced by myoepithelial cells inhibited terminal differentiation and enchondral ossification in pleomorphic adenomas. These results also suggest important roles for FGFs in the formation of various structures with mesenchymal-like histology.
碱性成纤维细胞生长因子和酸性成纤维细胞生长因子（bFGF和aFGF）是肝素结合生长因子，可促进纤维生成和血管生成。我们研究了bFGF、aFGF和FGF受体-1在多形性腺瘤中的免疫组化定位。在正常唾液腺中，bFGF定位于闰管、腺泡的基底膜以及排泄管的基底细胞，而aFGF局灶性定位于闰管细胞和排泄管的基底细胞。在多形性腺瘤中，bFGF免疫定位于肌上皮细胞实性巢周围的基底膜、黏液样区域的肿瘤性肌上皮细胞周围以及软骨样区域的陷窝细胞中。相比之下，软骨样区域对aFGF无免疫反应性。aFGF的阳性信号定位于多形性腺瘤中管状腺泡结构的管腔细胞。FGF受体-1免疫定位于实性和黏液样区域的陷窝细胞和肌上皮细胞。这些观察结果表明，肌上皮细胞产生的bFGF和FGF受体-1抑制了多形性腺瘤中的终末分化和软骨内成骨。这些结果还表明FGF在具有间充质样组织学的各种结构形成中起重要作用。
