Effects of herpesvirus infections on the chemiluminescence induced by zymosan phagocytosis in mouse peritoneal macrophages.

The chemiluminescence (CL) induced by zymosan phagocytosis was tested in mouse peritoneal macrophages infected with three different types of herpes viruses: herpes simplex type-1 (HSV-1), human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV). The intensity of CL was tested in various intervals of virus infections. In the first eight hours zymosan induced chemiluminescence decreased in all the three systems. By the 24th hour, the macrophages infected with HCMV had almost completely recovered from the early defect, while in the macrophages infected with both HSV-1 and MCMV, the chemiluminescence induced by zymosan remained impaired.