Shibutani Y
Department of Internal Medicine, Kouritsu Yanase Hospital, Hyogo, Japan.
Am J Med Sci. 1988 Feb;295(2):140-3. doi: 10.1097/00000441-198802000-00011.
Case of isolated ACTH deficiency accompanied by hyperprolactinemia was reported. Prolactin (PRL) secretory dynamics were evaluated by several stimulation (thyrotropin-releasing hormone [TRH], sulpiride) and suppression (L-dopa) tests. Before glucocorticoid replacement therapy, both TRH and sulpiride administration resulted in PRL hyper-responsiveness. The sulpiride-induced PRL increase was higher than that induced by TRH. L-dopa administration resulted in normal PRL suppression. Following glucocorticoid replacement therapy, the elevated basal PRL level returned to normal, and PRL hyper-responsiveness to TRH or sulpiride also returned to normal. These data suggest that the elevation of basal PRL level and PRL hyper-responsiveness observed in this patient is caused by glucocorticoid deficiency.
报告了一例孤立性促肾上腺皮质激素（ACTH）缺乏伴高催乳素血症的病例。通过多种刺激试验（促甲状腺激素释放激素[TRH]、舒必利）和抑制试验（左旋多巴）评估催乳素（PRL）的分泌动力学。在糖皮质激素替代治疗前，给予TRH和舒必利均导致PRL反应过度。舒必利诱导的PRL升高高于TRH诱导的升高。给予左旋多巴导致PRL正常抑制。糖皮质激素替代治疗后，升高的基础PRL水平恢复正常，PRL对TRH或舒必利的反应过度也恢复正常。这些数据表明，该患者观察到的基础PRL水平升高和PRL反应过度是由糖皮质激素缺乏引起的。
