过敏性哮喘患者外周α-肾上腺素能受体反应增强。
Increased peripheral alpha-adrenoceptor response in allergic asthmatics.
作者信息
Sandström T, Henriksson R, Hörnkvist R, Bäck O, Rosenhall L
机构信息
Dept. of Lung Medicine, University Hospital of Umeå, Sweden.
出版信息
Allergy. 1988 Jan;43(1):49-52. doi: 10.1111/j.1398-9995.1988.tb02043.x.
The peripheral alpha-adrenoceptor reactivity, measured as dermal blanching response to iontophoretically administered phenylephrine, was studied in 28 allergic asthmatics, 13 patients with allergic rhinoconjunctivitis and 21 healthy controls. The blanching response, which has previously been demonstrated to be mediated via alpha 1-adrenoceptors, was found to be significantly increased in allergic asthmatics compared with controls. It is suggested that there is an increased peripheral alpha-adrenoceptor reactivity in allergic asthma.
通过对离子电渗法给予去氧肾上腺素的皮肤变白反应来测量外周α-肾上腺素能受体反应性，该反应性在28名过敏性哮喘患者、13名过敏性鼻结膜炎患者和21名健康对照者中进行了研究。先前已证明变白反应是通过α1-肾上腺素能受体介导的，研究发现过敏性哮喘患者的变白反应与对照组相比显著增加。提示过敏性哮喘患者外周α-肾上腺素能受体反应性增加。
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