Tchórzewski H, Goch J H, Baj Z, Tkaczewski W
Department of Pathophysiology, Military Medical Academy, Lódź.
Arch Immunol Ther Exp (Warsz). 1987;35(4):405-12.
The human spontaneous cell-mediated cytotoxicity (SCMC) and lectin dependent cell-mediated cytotoxicity (LDCMC) of peripheral blood leukocytes (PBL) were studied in patients with different forms of postviral myocarditis. The PBL cytotoxicity was evaluated using 51Cr-labelled CRBC (chicken red blood cells) as targets and results were expressed as a percentage of specific release. The control group was represented by 150 healthy persons of both sexes. No significant age-related differences were found in SCMC and LDCMC activities of PBL from healthy persons. Myocarditis was diagnosed according to clinical criteria. All investigated myocarditis patients suffered from Coxsackie B or Echo-virus infections which were confirmed using virus neutralizing antibody test and haemagglutination inhibition test, respectively. The increase in the investigated cytotoxic cell activity in acute and exacerbated myocarditis and its normalization in chronic one may directly suggest the participation of these cells in heart injury.
我们研究了不同类型病毒性心肌炎患者外周血白细胞（PBL）的人类自发细胞介导细胞毒性（SCMC）和凝集素依赖性细胞介导细胞毒性（LDCMC）。使用51Cr标记的鸡红细胞（CRBC）作为靶标评估PBL细胞毒性，结果以特异性释放百分比表示。对照组由150名男女健康人组成。健康人PBL的SCMC和LDCMC活性未发现明显的年龄相关差异。心肌炎根据临床标准进行诊断。所有接受调查的心肌炎患者均感染了柯萨奇B病毒或埃可病毒，分别通过病毒中和抗体试验和血凝抑制试验得到证实。急性和加重期心肌炎中所研究的细胞毒性细胞活性增加，而在慢性期恢复正常，这可能直接表明这些细胞参与了心脏损伤。
