纤维连接蛋白-3和间皮素在恶性间皮瘤所致胸腔积液患者中的诊断性能比较

Comparison of the Diagnostic Performance of Fibulin-3 and Mesothelin in Patients with Pleural Effusions from Malignant Mesothelioma.

作者信息

Battolla Enrico, Canessa Pier Aldo, Ferro Paola, Franceschini Maria Cristiana, Fontana Vincenzo, Dessanti Paolo, Pinelli Valentina, Morabito Anna, Fedeli Franco, Pistillo Maria Pia, Roncella Silvio

机构信息

Division of Clinical Pathology, Azienda Sanitaria Locale n°5, La Spezia, Italy.

Division of Pneumology, Azienda Sanitaria Locale n°5, La Spezia, Italy.

出版信息

Anticancer Res. 2017 Mar;37(3):1387-1391. doi: 10.21873/anticanres.11460.

DOI:10.21873/anticanres.11460

PMID:28314308

Abstract

BACKGROUND

In the literature, there exist conflicting data on the value of fibulin-3 (FBLN3) for the diagnosis of pleural effusion (PE) in malignant pleural mesothelioma (MPM). Therefore we compared the diagnostic performance of FBLN3 against that of soluble mesothelin-related peptide (SMRP) in a cohort of Italian patients.

MATERIALS AND METHODS

FBLN3 and SMRP were detected in PE from 33 patients with MPM, 64 with pleural benign lesions and 23 with non-MPM pleural metastases using a commercial enzyme-linked-immunosorbent(ELISA)-assay kit according to manufacturers' instructions.

RESULTS

Levels of FBLN3 were similar in PE from MPM and PE from other pathologies (geometric mean=68.1 vs. 66.2 ng/ml; p=0.872) in contrast to SMRP levels, which were significantly higher in PE from MPM (geometric mean=14.6 vs. 3.2 nM; p<0.001). Receiver operating characteristic analysis confirmed that SMRP showed a good performance (area under the curve=0.79, p<0.001), whereas FBLN3 was not able to discriminate MPM from other pathologies (area under the curve=0.44, p=0.838).

CONCLUSION

FBLN3 detection in PE, in contrast to SMRP detection, is not useful as a biomarker for the diagnosis of PE from MPM.

摘要

背景

在文献中，关于纤维连接蛋白-3（FBLN3）在恶性胸膜间皮瘤（MPM）中诊断胸腔积液（PE）的价值存在相互矛盾的数据。因此，我们在一组意大利患者中比较了FBLN3与可溶性间皮素相关肽（SMRP）的诊断性能。

材料与方法

根据制造商的说明，使用商用酶联免疫吸附（ELISA）检测试剂盒，在33例MPM患者、64例胸膜良性病变患者和23例非MPM胸膜转移患者的胸腔积液中检测FBLN3和SMRP。

结果

与SMRP水平相反，MPM患者胸腔积液中的FBLN3水平与其他病理类型的胸腔积液中的FBLN3水平相似（几何平均值分别为68.1和66.2 ng/ml；p = 0.872），而MPM患者胸腔积液中的SMRP水平显著更高（几何平均值分别为14.6和3.2 nM；p < 0.001）。受试者工作特征分析证实，SMRP表现良好（曲线下面积 = 0.79，p < 0.001），而FBLN3无法区分MPM与其他病理类型（曲线下面积 = 0.44，p = 0.838）。