在急性早幼粒细胞白血病的t(3;17)(q26;q21)变异型中，FNDC3B是另一个与RARA融合的新型伙伴。 - Suppr

FNDC3B is another novel partner fused to RARA in the t(3;17)(q26;q21) variant of acute promyelocytic leukemia.

作者信息

Cheng Chi Keung, Wang Angela Z, Wong Terry H Y, Wan Thomas S K, Cheung Joyce S, Raghupathy Radha, Chan Natalie P H, Ng Margaret H L

机构信息

Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital.

Department of Clinical Oncology, Prince of Wales Hospital, and.

出版信息

Blood. 2017 May 11;129(19):2705-2709. doi: 10.1182/blood-2017-02-767707. Epub 2017 Mar 17.

DOI:10.1182/blood-2017-02-767707

PMID:28314734

Abstract

摘要

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FNDC3B is another novel partner fused to RARA in the t(3;17)(q26;q21) variant of acute promyelocytic leukemia.在急性早幼粒细胞白血病的t(3;17)(q26;q21)变异型中，FNDC3B是另一个与RARA融合的新型伙伴。

Blood. 2017 May 11;129(19):2705-2709. doi: 10.1182/blood-2017-02-767707. Epub 2017 Mar 17.

Identification of a novel TNRC18-RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML-RARA.在缺乏 t(15;17)(q24;q12)/PML-RARA 的急性早幼粒细胞白血病中鉴定出一种新型的 TNRC18-RARA 融合。

Mol Carcinog. 2021 Feb;60(2). doi: 10.1002/mc.23276. Epub 2021 Jan 11.

Acute promyelocytic leukaemia (APML) with cryptic PML-RARA fusion has a clinical course comparable to classical APML with t(15;17)(q24.1;q21.2) translocation.伴有隐匿性PML-RARA融合的急性早幼粒细胞白血病（APML）的临床病程与伴有t(15;17)(q24.1;q21.2)易位的经典APML相当。

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The leukemic oncoprotein NPM1-RARA inhibits TP53 activity.白血病癌蛋白NPM1-RARA抑制TP53活性。

Leuk Lymphoma. 2016 Aug;57(8):1933-7. doi: 10.3109/10428194.2015.1124992. Epub 2016 Jan 12.

TBLR1 fuses to retinoid acid receptor α in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia.TBLR1 与维甲酸受体 α 在急性早幼粒细胞白血病的变异 t(3;17)(q26;q21)易位中融合。

Blood. 2014 Aug 7;124(6):936-45. doi: 10.1182/blood-2013-10-528596. Epub 2014 Apr 29.

A novel t(3;17)(p25;q21) variant translocation of acute promyelocytic leukemia with rearrangement of the RARA locus.一种伴有RARA基因座重排的急性早幼粒细胞白血病的新型t(3;17)(p25;q21)变异易位。

Leukemia. 2006 Feb;20(2):376-9. doi: 10.1038/sj.leu.2404062.

Clinical and genomic characterization of an ATRA-insensitive acute promyelocytic leukemia variant with a FNDC3B::RARB fusion.一种 ATRA 不敏感的急性早幼粒细胞白血病变异体的临床和基因组特征，具有 FNDC3B::RARB 融合。

Genes Chromosomes Cancer. 2023 Oct;62(10):617-623. doi: 10.1002/gcc.23180. Epub 2023 Jun 7.

Identification of novel recurrent - fusions in acute promyelocytic leukemia lacking t(15;17)(q22;q12)/-.在缺乏t(15;17)(q22;q12)/-的急性早幼粒细胞白血病中鉴定新的复发性融合基因

Blood. 2018 Feb 22;131(8):935-939. doi: 10.1182/blood-2017-09-807370. Epub 2017 Dec 13.

BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia.BCOR 作为急性早幼粒细胞白血病 t(X;17)(p11;q12)变异型中 retinoic acid receptor alpha 的新型融合伙伴。

Blood. 2010 Nov 18;116(20):4274-83. doi: 10.1182/blood-2010-01-264432. Epub 2010 Aug 31.

Report of IRF2BP1 as a novel partner of RARA in variant acute promyelocytic leukemia.IRF2BP1 作为 RARA 新型伴侣在变异型急性早幼粒细胞白血病中的报告。

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FNDC3B is another novel partner fused to RARA in the t(3;17)(q26;q21) variant of acute promyelocytic leukemia.

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