在缺乏 t(15;17)(q24;q12)/PML-RARA 的急性早幼粒细胞白血病中鉴定出一种新型的 TNRC18-RARA 融合。
Identification of a novel TNRC18-RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML-RARA.
机构信息
National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, P.R. China.
Suzhou Jsuniwell Medical Laboratory, Suzhou, P.R. China.
出版信息
Mol Carcinog. 2021 Feb;60(2). doi: 10.1002/mc.23276. Epub 2021 Jan 11.
Acute promyelocytic leukemia (APL) is a unique disease entity in acute myeloid leukemia, characterized by PML-RARA fusion gene, which is generated by chromosomal translocation t(15;17)(q24;q21). We identified TNRC18-RARA as novel RARA fusion in resembling APL. Our study highlights the importance of combining multiple molecular techniques to characterize and optimally manage APL lacking classic t(15;17)(q24;q12)/PML-RARA fusion.
急性早幼粒细胞白血病（APL）是急性髓细胞白血病中的一种独特疾病实体，其特征在于存在 PML-RARA 融合基因，该基因由染色体易位 t(15;17)(q24;q21)产生。我们鉴定出 TNRC18-RARA 是一种新型的 RARA 融合基因，类似于 APL。我们的研究强调了结合多种分子技术来表征和最佳管理缺乏经典 t(15;17)(q24;q12)/PML-RARA 融合的 APL 的重要性。
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