Hariton C, Ciesielski L, Cano J P, Mandel P
INSERM U. 278, Faculté de Pharmacie, Marseille, France.
Neurosci Lett. 1988 Jan 11;84(1):97-102. doi: 10.1016/0304-3940(88)90344-8.
Among the large variety of epilepsy models, differences in binding parameters on benzodiazepine (BZD) receptors could be demonstrated in some of them. A new model of petit mal-like seizures occurring spontaneously has been described in a strain of Wistar rats. The purpose of this study was to investigate the binding parameters on 'central' type and 'peripheral' type BZD receptor sites in epileptic and non-epileptic animals of this strain. Thus, using [3H]flunitrazepam as ligand, no modification was observed for 'central' type BZD sites in cortex, cerebellum and hippocampus. Nevertheless, using [3H]Ro 5-4864 as ligand, an important increase (125-150%) in the affinity constant on 'peripheral' type BZD sites was observed in epileptic rats, namely a lower affinity for the ligand on this receptor. Finally, no change occurred in the ratio between 'central' and 'peripheral' BZD receptor site apparent numbers.
在种类繁多的癫痫模型中，部分模型的苯二氮䓬（BZD）受体结合参数存在差异。一种新的自发出现小发作样癫痫的模型已在Wistar大鼠品系中得以描述。本研究的目的是调查该品系癫痫和非癫痫动物中“中枢”型和“外周”型BZD受体位点的结合参数。因此，以[3H]氟硝西泮作为配体时，在皮质、小脑和海马体中“中枢”型BZD位点未观察到变化。然而，以[3H]Ro 5-4864作为配体时，在癫痫大鼠中观察到“外周”型BZD位点的亲和常数显著增加（125% - 150%），即在该受体上配体的亲和力较低。最后，“中枢”和“外周”BZD受体位点的表观数量之比未发生变化。
