红色诺卡氏菌细胞壁骨架促进CD4 T细胞活化并驱动Th1免疫反应。
Nocardia rubra cell-wall skeleton promotes CD4 T cell activation and drives Th1 immune response.
作者信息
Wang Guangchuan, Wu Jie, Miao Miao, Dou Heng, Nan Ning, Shi Mingsheng, Yu Guang, Shan Fengping
机构信息
Department of Immunology, School of Basic Medical Science, Jinzhou Medical University, No. 40, Section 3, Songpo Road, Linghe District, Jinzhou 121000, China.
Department of Oncology, First Affiliated Hospital of Jinzhou Medical University, No. 5-2,Renmin Street, Guta District, Jinzhou, 121001, China.
出版信息
Int J Biol Macromol. 2017 Aug;101:398-407. doi: 10.1016/j.ijbiomac.2017.03.060. Epub 2017 Mar 15.
Several lines of evidences have shown that Nocardia rubra cell wall skeleton (Nr-CWS) has immunoregulatory and anti-tumor activities. However, there is no information about the effect of Nr-CWS on CD4 T cells. The aim of this study was to explore the effect of Nr-CWS on the phenotype and function of CD4 T cells. Our results of in vitro experiments showed that Nr-CWS could significantly up-regulate the expression of CD69 and CD25 on CD4 T cells, promote the proliferation of CD4 T cells, increase the production of IFN-γ, TNF-α and IL-2 in the supernatants, but has no significant effect on the apoptosis and death of CD4 T cells. Results of in vivo experiments showed that Nr-CWS could promote the proliferation of CD4 T cells, and increase the production of IL-2, IFN-γ and TNF-α (Th1 type cytokines). These data suggest that Nr-CWS can enhance the activation of CD4 T cells, promote the proliferation of CD4 T cells and the differentiation of CD4 T cells to Th1 cells.
多项证据表明，红色诺卡氏菌细胞壁骨架（Nr-CWS）具有免疫调节和抗肿瘤活性。然而，关于Nr-CWS对CD4 T细胞影响的信息却未见报道。本研究的目的是探讨Nr-CWS对CD4 T细胞表型和功能的影响。我们的体外实验结果表明，Nr-CWS可显著上调CD4 T细胞上CD69和CD25的表达，促进CD4 T细胞的增殖，增加上清液中IFN-γ、TNF-α和IL-2的产生，但对CD4 T细胞的凋亡和死亡无显著影响。体内实验结果表明，Nr-CWS可促进CD4 T细胞的增殖，并增加IL-2、IFN-γ和TNF-α（Th1型细胞因子）的产生。这些数据表明，Nr-CWS可增强CD4 T细胞的活化，促进CD4 T细胞的增殖以及CD4 T细胞向Th1细胞的分化。
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