Nakamura T, Shiraishi N, Aono K
Department of Radiation Medicine, Okayama University Medical School, Japan.
Physiol Chem Phys Med NMR. 1987;19(3):147-51.
The effects of zinc on the rate of production of bactericidal O2- of polymorphonuclear leukocytes (PMN) in response to three different types of stimulating agents (serum-treated zymosan (STZ), Con A, and myristate) were studied. The percentage reduction of O2- production of PMN stimulated by STZ, Con A, and myristate were all reduced in response to Zn, irregardless of whether Zn was added to the reaction mixture immediately before SZT addition or following a prior 20 min. incubation of PMN in the presence of Zn. However, when Zn was introduced intraperitonially into guinea pigs before the collection of PMN from the animal, zinc treatment produced inhibition only in STZ-activated PMN; it produced no effect in O2- production of PMN stimulated by myristate, and it further augmented the O2- production stimulated by Con A.
研究了锌对多形核白细胞（PMN）响应三种不同刺激剂（血清处理的酵母聚糖（STZ）、刀豆蛋白A（Con A）和肉豆蔻酸盐）产生杀菌性超氧阴离子（O2-）速率的影响。无论在添加STZ之前立即将锌添加到反应混合物中，还是在锌存在下先将PMN孵育20分钟后添加STZ，锌都会使受STZ、Con A和肉豆蔻酸盐刺激的PMN的O2-产生减少百分比降低。然而，当在从动物收集PMN之前将锌腹膜内注入豚鼠时，锌处理仅对STZ激活的PMN产生抑制作用；对肉豆蔻酸盐刺激的PMN的O2-产生没有影响，并且进一步增强了Con A刺激的O2-产生。
