Paulson G W
J Am Dent Assoc. 1979 Mar;98(3):410-1. doi: 10.14219/jada.archive.1979.0055.
With the use of nitrous oxide increasing, overuse and excessive exposure to this gas are also more prevalent. Neuropathy, expressed as amnesia, aphasia or weakness, numbness, and incoordination affecting all extremities, is the common result of frequent overexposure. For optimal dental treatment, it is recommended that both patient and dentist be aware that nitrous oxide can be an exogenous toxin, damaging to neuronal structures, if used in excess.
随着氧化亚氮使用的增加，该气体的过度使用和过度暴露也更为普遍。神经病变表现为失忆、失语，或影响四肢的无力、麻木和运动不协调，是频繁过度暴露的常见后果。为了获得最佳的牙科治疗效果，建议患者和牙医都应意识到，如果过量使用，氧化亚氮可能成为一种外源性毒素，损害神经元结构。
