Gutmann L, Farrell B, Crosby T W, Johnsen D
J Am Dent Assoc. 1979 Jan;98(1):58-9. doi: 10.14219/jada.archive.1979.0009.
The myelopathy and neuropathy associated with chronic misuse of nitrous oxide are potentially reversible if the habit is discontinued. This occurred in each of the reported cases, including our case, when it was transiently discontinued. Although a causal relationship between nitrous oxide and this myelopathy-neuropathy has not been proved, the circumstantial evidence is convincing. Both physicians and dentists should be aware of this potentially serious complication of chronic self-administration of nitrous oxide, especially in persons inclined to misuse drugs. Dentists, with their access to nitrous oxide, may be particularly at risk.
如果停止长期滥用一氧化二氮的习惯，与之相关的脊髓病和神经病有可能恢复。在包括我们的病例在内的每例报告病例中，当短暂停止使用时，情况都是如此。尽管一氧化二氮与这种脊髓病 - 神经病之间的因果关系尚未得到证实，但间接证据很有说服力。医生和牙医都应意识到长期自行使用一氧化二氮可能出现的这种严重并发症，尤其是对于有药物滥用倾向的人。牙医能够接触到一氧化二氮，可能面临特别的风险。
