Tsai Ming-Chieh, Lin Herng-Ching, Lee Cha-Ze
Division of Gastroenterology, Department of Internal Medicine, Hsinchu Cathay General Hospital, Hsinchu, Taiwan.
School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.
Clin Endocrinol (Oxf). 2017 Jun;86(6):825-829. doi: 10.1111/cen.13332. Epub 2017 Apr 12.
Ulcerative colitis (UC) is a chronic relapsing inflammatory disease with significant clinical diversity. However, the aetiology, pathogenesis and optimal treatment of UC remain unclear. The purpose of this case-control study was to investigate the association between previously diagnosed hyperthyroidism and UC using a large population-based data set in Taiwan.
The data for this population-based case-control study were retrieved from the Taiwan Longitudinal Health Insurance Database 2005. We included 2709 patients with UC as cases and 8127 sex- and age-matched patients without UC as controls. A conditional logistic regression analysis was conducted to compute the odds ratio (OR) and corresponding 95% confidence interval (CI) for the association between UC and prior hyperthyroidism.
We found that, in total, 327 of the 10 836 sampled patients (3.02%) had previously been diagnosed with hyperthyroidism. There was a higher proportion of prior hyperthyroidism among cases than controls (4.10% vs 2.66%, P<.001). A conditional logistic regression showed that the OR of prior hyperthyroidism was 1.57 (95% CI=1.24-1.98) compared to controls. Similarly, after adjusting for monthly income, geographic location and urbanization level, cases were still more likely to have previously been diagnosed with hyperthyroidism than controls (OR=1.61, 95% CI=1.27-2.05). Furthermore, we analysed the ORs of prior hyperthyroidism between cases and controls according to age group. We found that of the youngest group of sampled patients (18-39 years), cases had the greatest adjusted OR for having previously been diagnosed with hyperthyroidism than controls (OR=1.98, 95% CI=1.04-3.79).
This study demonstrated an association between UC and hyperthyroidism.
溃疡性结肠炎（UC）是一种具有显著临床多样性的慢性复发性炎症性疾病。然而，UC的病因、发病机制和最佳治疗方法仍不明确。本病例对照研究的目的是利用台湾一个基于人群的大型数据集，调查先前诊断的甲状腺功能亢进症与UC之间的关联。
本基于人群的病例对照研究的数据取自2005年台湾纵向健康保险数据库。我们纳入了2709例UC患者作为病例组，以及8127例性别和年龄匹配的非UC患者作为对照组。进行条件逻辑回归分析，以计算UC与既往甲状腺功能亢进症之间关联的比值比（OR）和相应的95%置信区间（CI）。
我们发现，在总共10836例抽样患者中，有327例（3.02%）先前被诊断为甲状腺功能亢进症。病例组中既往甲状腺功能亢进症的比例高于对照组（4.10%对2.66%，P<0.001）。条件逻辑回归显示，与对照组相比，既往甲状腺功能亢进症的OR为1.57（95%CI=1.24-1.98）。同样，在调整月收入、地理位置和城市化水平后，病例组仍比对照组更有可能先前被诊断为甲状腺功能亢进症（OR=1.61，95%CI=1.27-至2.05）。此外，我们根据年龄组分析了病例组和对照组之间既往甲状腺功能亢进症的OR。我们发现，在最年轻的抽样患者组（18-39岁）中，病例组先前被诊断为甲状腺功能亢进症的调整后OR比对照组最大（OR=1.98，95%CI=1.04-3.79）。
本研究证明了UC与甲状腺功能亢进症之间存在关联。
