Zhou R X, Li Y Y, Lin W H, Li G, Sun J E, Zhou W B
Department of Burns and Plastic Surgery, Guangzhou Red Cross Hospital, Ji'nan University, Guangzhou 510220, China.
Zhonghua Shao Shang Za Zhi. 2017 Mar 20;33(3):190-192. doi: 10.3760/cma.j.issn.1009-2587.2017.03.015.
Previous studies have demonstrated that integrin-linked kinases (ILKs) are abundantly expressed in extracellular matrix (ECM) riche dermis, hair follicles, and basal cells of epidermis. ILKs are not only essential for the maintenance of skin structure, but also play important roles in wound healing. ILKs can promote the formation of granulation tissue by stimulating the proliferation of fibroblasts and secretion of ECM, accelerate wound contraction by inducing the differentiation of fibroblasts to myofibroblasts, and boost reepithelization by promoting proliferation, migration, and differentiation of keratinocytes and follicle epidermal stem cells.
先前的研究表明，整合素连接激酶（ILKs）在富含细胞外基质（ECM）的真皮、毛囊和表皮基底细胞中大量表达。ILKs不仅对维持皮肤结构至关重要，而且在伤口愈合中也发挥着重要作用。ILKs可通过刺激成纤维细胞增殖和ECM分泌来促进肉芽组织形成，通过诱导成纤维细胞向肌成纤维细胞分化来加速伤口收缩，并通过促进角质形成细胞和毛囊表皮干细胞的增殖、迁移和分化来促进表皮再生。
